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Hakkak R, Bell A, Korourian S. Dehydroepiandrosterone (DHEA) Feeding Protects Liver Steatosis in Obese Breast Cancer Rat Model. Sci Pharm. 2017;85(1)doi: 10.3390/scipharm85010013.
Hakkak, R., Bell, A., & Korourian, S. (2017). Dehydroepiandrosterone (DHEA) Feeding Protects Liver Steatosis in Obese Breast Cancer Rat Model. Scientia pharmaceutica, 85(1), . https://doi.org/10.3390/scipharm85010013
Hakkak, Reza, et al. "Dehydroepiandrosterone (DHEA) Feeding Protects Liver Steatosis in Obese Breast Cancer Rat Model." Scientia pharmaceutica vol. 85,1 (2017). doi: https://doi.org/10.3390/scipharm85010013
Hakkak R, Bell A, Korourian S. Dehydroepiandrosterone (DHEA) Feeding Protects Liver Steatosis in Obese Breast Cancer Rat Model. Sci Pharm. 2017 Mar 20;85(1). doi: 10.3390/scipharm85010013. PMID: 28335515; PMCID: PMC5388150.
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Sci Pharm. 2017 Mar 20;85(1). doi: 10.3390/scipharm85010013.

Dehydroepiandrosterone (DHEA) Feeding Protects Liver Steatosis in Obese Breast Cancer Rat Model.

Scientia pharmaceutica

Reza Hakkak, Andrea Bell, Soheila Korourian

Affiliations

  1. Department of Dietetics and Nutrition, 4301 W. Markham St., Mail Slot 627, Little Rock, AR 72205, USA. [email protected].
  2. Pediatrics, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA. [email protected].
  3. Arkansas Children's Research Institute, 13 Children's Way, Little Rock, AR 72202, USA. [email protected].
  4. Department of Dietetics and Nutrition, 4301 W. Markham St., Mail Slot 627, Little Rock, AR 72205, USA. [email protected].
  5. Department of Pathology, University of Arkansas for Medical Sciences, W. Markham St., Little Rock, AR 72205, USA. [email protected].

PMID: 28335515 PMCID: PMC5388150 DOI: 10.3390/scipharm85010013

Abstract

Obesity is a major health problem in the US and globally. Obesity is associated with the risk of cardiovascular disease, type 2 diabetes, cancers, hyperlipidemia, and liver steatosis development. Dehydroepiandrosterone (DHEA) is a dietary supplement used as an anti-obesity supplement. Previously, we reported that DHEA feeding protects 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors. The objectives of this study were to investigate the effects of obesity and DHEA feeding on liver steatosis, body weight gain, and serum DHEA, DHEA sulfate (DHEA-S), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding protein-3 (IGFBP-3) levels. Female Zucker rats were randomly assigned to either a control diet or a control diet with DHEA supplementation for 155 days. Livers were collected for histological examination. Serum was collected to measure DHEA, DHEA-S, IGF-1, and IGFBP-3. Our results show that DHEA-fed rats had significantly less liver steatosis (

Keywords: DHEA; liver steatosis; obesity; weight loss

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