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Front Endocrinol (Lausanne). 2017 Mar 02;8:38. doi: 10.3389/fendo.2017.00038. eCollection 2017.

Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters .

Frontiers in endocrinology

Trine Maxel, Pernille Fog Svendsen, Kamille Smidt, Jesper Krogh Lauridsen, Birgitte Brock, Steen Bønlykke Pedersen, Jørgen Rungby, Agnete Larsen

Affiliations

  1. Faculty of Health, Department of Biomedicine, Aarhus University , Aarhus , Denmark.
  2. Department of Obstetrics and Gynecology, Herlev University Hospital , Herlev , Denmark.
  3. Faculty of Health, Department of Clinical Medicine, Aarhus University , Aarhus , Denmark.
  4. Department of Clinical Biochemistry, Aarhus University Hospital , Aarhus , Denmark.
  5. Faculty of Health, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Endocrinology (MEA), Aarhus University Hospital, Aarhus, Denmark.
  6. Center for Diabetes Research, Department of Medicine, Gentofte University Hospital , Hellerup , Denmark.

PMID: 28303117 PMCID: PMC5332389 DOI: 10.3389/fendo.2017.00038

Abstract

Polycystic ovary syndrome (PCOS) is associated with infertility, increased androgen levels, and insulin resistance. In adipose tissue, zinc facilitates insulin signaling. Circulating zinc levels are altered in obesity, diabetes, and PCOS; and zinc supplementation can ameliorate metabolic disturbances in PCOS. In adipose tissue, expression of zinc influx transporter

Keywords: Slc30a; Slc39a; ZIP14; ZNT1; obesity; peroxisome proliferator-activated receptor gamma; polycystic ovary syndrome; zinc

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