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Reddy MK, Reddy AG, Kumar BK, et al. Protective effect of rutin in comparison to silymarin against induced hepatotoxicity in rats. Vet World. 2017;10(1):74-80doi: 10.14202/vetworld.2017.74-80.
Reddy, M. K., Reddy, A. G., Kumar, B. K., Madhuri, D., Boobalan, G., & Reddy, M. A. (2017). Protective effect of rutin in comparison to silymarin against induced hepatotoxicity in rats. Veterinary world, 10(1), 74-80. https://doi.org/10.14202/vetworld.2017.74-80
Reddy, M Kasi, et al. "Protective effect of rutin in comparison to silymarin against induced hepatotoxicity in rats." Veterinary world vol. 10,1 (2017): 74-80. doi: https://doi.org/10.14202/vetworld.2017.74-80
Reddy MK, Reddy AG, Kumar BK, Madhuri D, Boobalan G, Reddy MA. Protective effect of rutin in comparison to silymarin against induced hepatotoxicity in rats. Vet World. 2017 Jan;10(1):74-80. doi: 10.14202/vetworld.2017.74-80. Epub 2017 Jan 19. PMID: 28246450; PMCID: PMC5301182.
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Vet World. 2017 Jan;10(1):74-80. doi: 10.14202/vetworld.2017.74-80. Epub 2017 Jan 19.

Protective effect of rutin in comparison to silymarin against induced hepatotoxicity in rats.

Veterinary world

M Kasi Reddy, A Gopala Reddy, B Kala Kumar, D Madhuri, G Boobalan, M Anudeep Reddy

Affiliations

  1. Department of Veterinary Pharmacology and Toxicology, P V Narsimha Rao Telangana Veterinary University, College of Veterinary Science, Rajendranagar, Hyderabad - 500 030, Telangana, India.
  2. Department of Veterinary Pathology, P V Narsimha Rao Telangana Veterinary University, College of Veterinary Science, Rajendranagar, Hyderabad - 500 030, Telangana, India.

PMID: 28246450 PMCID: PMC5301182 DOI: 10.14202/vetworld.2017.74-80

Abstract

AIM: The aim of this study is to evaluate the hepatoprotective effect of rutin (RTN) in comparison to silymarin (SLM) against acetaminophen (APAP)-induced hepatotoxicity in rats.

MATERIALS AND METHODS: Male Wistar albino rats (n=24) of 3 months age were equally divided into four groups. Group 1 served as normal control. Hepatotoxicity was induced in the remaining three groups with administration of 500 mg/kg po APAP from day 1-3. Groups 2, 3, and 4 were subsequently administered orally with distilled water, 25 mg/kg of SLM, and 20 mg/kg of RTN, respectively, for 11 days. The mean body weights and biomarkers of hepatotoxicity were estimated on day 0, 4 (confirmation of toxicity), and 15 (at the end of treatment). Hematological parameters were evaluated on day 4 and 15. Antioxidant profile and adenosine triphosphatases (ATPases) were assessed at the end of the experiment. Liver tissues were subjected to histopathology and transmission electron microscopy after the sacrifice on day 15.

RESULTS: Antioxidant profile, ATPases, and hematological and sero-biochemical parameters were significantly altered, and histopathological changes were noticed in the liver of toxic control group. These changes were reversed in groups 3 and 4 that were administered with SLM and RTN, respectively.

CONCLUSION: The results of the present investigation enunciated that SLM has potent hepatoprotective activity though the RTN was found superior in restoring the pathological alterations in paracetamol-induced hepatotoxicity in Wistar albino rats.

Keywords: acetaminophen; hepatotoxicity; rutin; silymarin

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