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Nadal C. Controle de la multiplication et de la polyploïdie des hepatocytes du rat : étude des perturbations de la régulation physiologique causées par l'injection de produits irritants. [Control of multiplication and polyploidy of rat hepatocytes : A study of the perturbations of physiological regulation induced by injection of irritants]. Wilhelm Roux Arch Entwickl Mech Org. 1970;166(2):136-149doi: 10.1007/BF00576990.
Nadal, C. (1970). Controle de la multiplication et de la polyploïdie des hepatocytes du rat : étude des perturbations de la régulation physiologique causées par l'injection de produits irritants. [Control of multiplication and polyploidy of rat hepatocytes : A study of the perturbations of physiological regulation induced by injection of irritants]. Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen, 166(2), 136-149. https://doi.org/10.1007/BF00576990
Nadal, C. "Controle de la multiplication et de la polyploïdie des hepatocytes du rat : étude des perturbations de la régulation physiologique causées par l'injection de produits irritants." [Control of multiplication and polyploidy of rat hepatocytes : A study of the perturbations of physiological regulation induced by injection of irritants]. Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen vol. 166,2 (1970): 136-149. doi: https://doi.org/10.1007/BF00576990
Nadal C. Controle de la multiplication et de la polyploïdie des hepatocytes du rat : étude des perturbations de la régulation physiologique causées par l'injection de produits irritants. [Control of multiplication and polyploidy of rat hepatocytes : A study of the perturbations of physiological regulation induced by injection of irritants]. Wilhelm Roux Arch Entwickl Mech Org. 1970 Jun;166(2):136-149. doi: 10.1007/BF00576990. French. PMID: 28304789.
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Wilhelm Roux Arch Entwickl Mech Org. 1970 Jun;166(2):136-149. doi: 10.1007/BF00576990.

[Control of multiplication and polyploidy of rat hepatocytes : A study of the perturbations of physiological regulation induced by injection of irritants].

Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen

[Article in French]
C Nadal

Affiliations

  1. Unité de Physiologie Cellulaire, Inserm, Institut du Radium, Orsay (91), France.

PMID: 28304789 DOI: 10.1007/BF00576990

Abstract

The injection of irritating substances of various chemical nature disturbs the mechanisms regulating the multiplication of rat hepatocytes.The reaction of baby rats is intense and reproducible. It results, 15 hours after the injection, in an increase of the number of cells entering the S phase, so that practically all the divisions which would normally have been scattered over 36 hours are initiated within 2 hours. This burst of synchronized mitosis corresponding to a 36 hours advance in the hepatic growth is followed by a decrease of mitoses due to a feed-back inhibition.The reaction of older rats brings to evidence a permanent inhibitory mechanism that results in a less regular and intensive response.The production of binucleated and polyploÏd hepatocytes seems to be correlated to this inhibitory mechanism.The regularity and sensivity of the baby rat reactions make them a choice material for the study of hepatic growth.

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