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Wilehm Roux Arch Dev Biol. 1981 Jan;190(1):60-61. doi: 10.1007/BF00868706.

Effects of cycloheximide on cellular elongation in aManduca sexta cell line.

Wilhelm Roux's archives of developmental biology

H Oberlander, C E Leach, D E Lynn

Affiliations

  1. Insect Attractants, Behavior and Basic Biology Research Laboratory, Agricultural Research, Science and Education Administration, USDA, 32604, Gainesville, Florida, USA.
  2. Department of Entomology, University of Florida, 32611, Gainesville, Florida, USA.

PMID: 28305373 DOI: 10.1007/BF00868706

Abstract

A clone (GV1) of the CHIManduca sexta cell line responds to 20-hydroxy-ecdysone by changing cellular shape from an epithelial-like form to an elongated fibroblast-like form. We have determined that this morphological response to hormone is prevented by treatment with cycloheximide. The inhibition of the elongation response by cycloheximide may relate to a requirement for the synthesis of specific proteins that play a role in the formation of cytoskeletal structure.

Keywords: 20-hydroxy-ecdysone, insect tissue culture; Cycloheximide; Manduca sexta

References

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