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Greger V, Berking S. Nerve cell production in Hydra is deregulated by tumour-promoting phorbol ester. Rouxs Arch Dev Biol. 1991;200(4):234-236doi: 10.1007/BF00361343.
Greger, V., & Berking, S. (1991). Nerve cell production in Hydra is deregulated by tumour-promoting phorbol ester. Roux's archives of developmental biology : the official organ of the EDBO, 200(4), 234-236. https://doi.org/10.1007/BF00361343
Greger, Valerie, and Berking, Stefan. "Nerve cell production in Hydra is deregulated by tumour-promoting phorbol ester." Roux's archives of developmental biology : the official organ of the EDBO vol. 200,4 (1991): 234-236. doi: https://doi.org/10.1007/BF00361343
Greger V, Berking S. Nerve cell production in Hydra is deregulated by tumour-promoting phorbol ester. Rouxs Arch Dev Biol. 1991 Sep;200(4):234-236. doi: 10.1007/BF00361343. PMID: 28305972.
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Rouxs Arch Dev Biol. 1991 Sep;200(4):234-236. doi: 10.1007/BF00361343.

Nerve cell production in Hydra is deregulated by tumour-promoting phorbol ester.

Roux's archives of developmental biology : the official organ of the EDBO

Valerie Greger, Stefan Berking

Affiliations

  1. Zoologisches Institut der Universität zu Köln, Weyertal 119, W-5000, Köln, Federal Republic of Germany.

PMID: 28305972 DOI: 10.1007/BF00361343

Abstract

The tumour-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) interfers with nerve cell production in Hydra when applied to the animals' culture medium. Precursor cells exposed to 0.2 nM TPA during the first half of their S-phase are prevented from differentiating into nerve cells. Precursor cells which start their S-phase following a treatment with TPA give rise to nerve cells. The frequency is higher than in untreated control animals.

Keywords: Differentiation; Hydra; Nerve cells; Tumour-promoting phorbol esters

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