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Bhosale PG, Cristea S, Ambatipudi S, et al. Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer. Transl Oncol. 2017;10(3):396-409doi: 10.1016/j.tranon.2017.03.008.
Bhosale, P. G., Cristea, S., Ambatipudi, S., Desai, R. S., Kumar, R., Patil, A., Kane, S., Borges, A. M., Schäffer, A. A., Beerenwinkel, N., & Mahimkar, M. B. (2017). Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer. Translational oncology, 10(3), 396-409. https://doi.org/10.1016/j.tranon.2017.03.008
Bhosale, Priyanka G, et al. "Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer." Translational oncology vol. 10,3 (2017): 396-409. doi: https://doi.org/10.1016/j.tranon.2017.03.008
Bhosale PG, Cristea S, Ambatipudi S, Desai RS, Kumar R, Patil A, Kane S, Borges AM, Schäffer AA, Beerenwinkel N, Mahimkar MB. Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer. Transl Oncol. 2017 Jun;10(3):396-409. doi: 10.1016/j.tranon.2017.03.008. Epub 2017 Apr 21. PMID: 28433800; PMCID: PMC5403767.
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Transl Oncol. 2017 Jun;10(3):396-409. doi: 10.1016/j.tranon.2017.03.008. Epub 2017 Apr 21.

Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer.

Translational oncology

Priyanka G Bhosale, Simona Cristea, Srikant Ambatipudi, Rajiv S Desai, Rajiv Kumar, Asawari Patil, Shubhada Kane, Anita M Borges, Alejandro A Schäffer, Niko Beerenwinkel, Manoj B Mahimkar

Affiliations

  1. Cancer Research Institute (CRI), Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Navi Mumbai, 410210, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, 400085, India.
  2. Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland; SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland.
  3. Cancer Research Institute (CRI), Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Navi Mumbai, 410210, India; MRC Integrative Epidemiology Unit, University of Bristol, BS8 1TH, UK.
  4. Department of Oral Pathology & Microbiology, Nair Hospital Dental College, Mumbai, 400 008, India.
  5. Department of Pathology, Tata Memorial Hospital, Tata Memorial Centre (TMC), Parel, Mumbai, 400012, India.
  6. Department of Pathology & Laboratory Medicine, S. L. Raheja Hospital, Mumbai, 400016, India.
  7. Computational Biology Branch, National Center for Biotechnology Information, National Institute of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD, 20894, USA.
  8. Cancer Research Institute (CRI), Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Navi Mumbai, 410210, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, 400085, India. Electronic address: [email protected].

PMID: 28433800 PMCID: PMC5403767 DOI: 10.1016/j.tranon.2017.03.008

Abstract

We present an integrative genome-wide analysis that can be used to predict the risk of progression from leukoplakia to oral squamous cell carcinoma (OSCC) arising in the gingivobuccal complex (GBC). We find that the genomic and transcriptomic profiles of leukoplakia resemble those observed in later stages of OSCC and that several changes are associated with this progression, including amplification of 8q24.3, deletion of 8p23.2, and dysregulation of DERL3, EIF5A2, ECT2, HOXC9, HOXC13, MAL, MFAP5 and NELL2. Comparing copy number profiles of primary tumors with and without lymph-node metastasis, we identify alterations associated with metastasis, including amplifications of 3p26.3, 8q24.21, 11q22.1, 11q22.3 and deletion of 8p23.2. Integrative analysis reveals several biomarkers that have never or rarely been reported in previous OSCC studies, including amplifications of 1p36.33 (attributable to MXRA8), 3q26.31 (EIF5A2), 9p24.1 (CD274), and 12q13.2 (HOXC9 and HOXC13). Additionally, we find that amplifications of 1p36.33 and 11q22.1 are strongly correlated with poor clinical outcome. Overall, our findings delineate genomic changes that can be used in treatment management for patients with potentially malignant leukoplakia and OSCC patients with higher risk of lymph-node metastasis.

Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

References

  1. BMC Cancer. 2009 Jan 12;9:11 - PubMed
  2. Cell Adh Migr. 2010 Apr-Jun;4(2):169-71 - PubMed
  3. PLoS One. 2010 Nov 29;5(11):e14082 - PubMed
  4. Clin Cancer Res. 2011 Nov 15;17(22):7024-34 - PubMed
  5. Cancer Res. 2006 Aug 15;66(16):8210-8 - PubMed
  6. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Nov;122(5):609-618.e7 - PubMed
  7. Clin Cancer Res. 2016 Aug 1;22(15):3718-24 - PubMed
  8. Scand J Dent Res. 1987 Dec;95(6):449-55 - PubMed
  9. Mol Ther. 2014 May;22(5):999-1007 - PubMed
  10. Int J Clin Oncol. 2011 Feb;16(1):5-14 - PubMed
  11. Oral Oncol. 2014 May;50(5):404-12 - PubMed
  12. Mol Carcinog. 2006 Oct;45(10):721-31 - PubMed
  13. J Cancer. 2016 Apr 10;7(7):768-73 - PubMed
  14. Glia. 2003 Dec;44(3):190-204 - PubMed
  15. Int J Clin Exp Pathol. 2015 Sep 01;8(9):11884-94 - PubMed
  16. Genes Cancer. 2013 Nov;4(11-12):460-75 - PubMed
  17. Gastroenterology. 2014 Jun;146(7):1701-13.e9 - PubMed
  18. Am J Pathol. 2015 Jun;185(6):1600-9 - PubMed
  19. Cell. 2013 Jan 31;152(3):394-405 - PubMed
  20. PLoS One. 2015 Mar 20;10(3):e0119229 - PubMed
  21. Oncol Rep. 2011 Aug;26(2):463-9 - PubMed
  22. J Natl Cancer Inst. 2004 Jul 7;96(13):998-1006 - PubMed
  23. Cell. 2011 Mar 4;144(5):646-74 - PubMed
  24. Breast Cancer. 2015 Nov;22(6):602-7 - PubMed
  25. Oral Oncol. 2014 Jul;50(7):627-32 - PubMed
  26. Clin Cancer Res. 2000 May;6(5):1702-10 - PubMed
  27. J Biol Chem. 2002 Feb 1;277(5):3718-26 - PubMed
  28. Cancer Prev Res (Phila). 2008 Nov;1(6):424-9 - PubMed
  29. Br J Cancer. 2014 Apr 2;110(7):1767-77 - PubMed
  30. Mol Cancer. 2009 Jul 23;8:50 - PubMed
  31. Genes Chromosomes Cancer. 2014 Dec;53(12):972-90 - PubMed
  32. Clin Cancer Res. 2006 Nov 15;12(22):6594-7 - PubMed
  33. PLoS One. 2011 Feb 28;6(2):e17250 - PubMed
  34. Nat Commun. 2014 Oct 03;5:5092 - PubMed
  35. Int J Cancer. 2009 Jun 15;124(12):2864-71 - PubMed
  36. CA Cancer J Clin. 2002 Jul-Aug;52(4):195-215 - PubMed
  37. RSC Adv. 2013 Jan 1;3(10):3260-3269 - PubMed
  38. Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2152-62 - PubMed
  39. Cancer Res. 2011 Jun 15;71(12):4314-24 - PubMed
  40. Head Neck Pathol. 2007 Sep;1(1):61-6 - PubMed
  41. Br J Cancer. 2011 Jan 18;104(2):376-86 - PubMed
  42. Cell Prolif. 2015 Apr;48(2):249-58 - PubMed
  43. Clin Cancer Res. 2016 Sep 15;22(18):4643-50 - PubMed
  44. Diagn Pathol. 2012 Sep 14;7:120 - PubMed
  45. Cancer Res. 2001 May 1;61(9):3806-9 - PubMed
  46. Oral Oncol. 2015 Mar;51(3):221-8 - PubMed
  47. Curr Mol Med. 2008 Sep;8(6):446-58 - PubMed
  48. Int J Oncol. 2011 Oct;39(4):761-9 - PubMed
  49. Semin Radiat Oncol. 2008 Apr;18(2):98-104 - PubMed
  50. Clin Cancer Res. 2009 Feb 15;15(4):1353-61 - PubMed
  51. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D284-8 - PubMed
  52. Oncotarget. 2014 Aug 30;5(16):6716-33 - PubMed
  53. Genes Chromosomes Cancer. 2012 Feb;51(2):161-73 - PubMed
  54. Oral Surg Oral Med Oral Pathol. 1988 Feb;65(2):199-207 - PubMed
  55. Clin Cancer Res. 2009 Mar 1;15(5):1779-86 - PubMed
  56. Lancet Oncol. 2008 Jul;9(7):667-75 - PubMed
  57. Naturwissenschaften. 2003 May;90(5):193-211 - PubMed
  58. Genome Res. 2003 Sep;13(9):2129-41 - PubMed
  59. Hepatology. 2000 Mar;31(3):601-5 - PubMed
  60. Oncol Res. 2006;16(5):217-24 - PubMed
  61. Cancer Biol Ther. 2009 May;8(10):907-16 - PubMed
  62. Oral Oncol. 2011 Dec;47(12):1148-53 - PubMed
  63. Cancer Res. 2013 Mar 15;73(6):1733-41 - PubMed
  64. Int J Cancer. 2014 Oct 1;135(7):1653-61 - PubMed
  65. J Transl Med. 2012 May 14;10:91 - PubMed
  66. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):5960-71 - PubMed
  67. BMC Genomics. 2013 Nov 25;14:830 - PubMed
  68. J Mol Med (Berl). 2014 Aug;92(8):811-23 - PubMed
  69. Acta Otolaryngol. 2013 Sep;133(9):992-9 - PubMed

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