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Contemp Oncol (Pozn). 2016;20(5):365-373. doi: 10.5114/wo.2016.64594. Epub 2016 Dec 20.

Comparison of clinical pharmacology of voriconazole and posaconazole.

Contemporary oncology (Poznan, Poland)

Beata M Sienkiewicz, Łukasz Łapiński, Anna Wiela-Hojeńska

Affiliations

  1. Wroclaw Medical University, Wroclaw, Poland.

PMID: 28373817 PMCID: PMC5371702 DOI: 10.5114/wo.2016.64594

Abstract

Despite greater knowledge and possibilities in pharmacotherapy, fungal infections remain a challenge for clinicians. As the population of immunocompromised patients and those treated for their hematologic ailments increases, the number of fungal infections grows too. This is why there is still a quest for new antifungal drugs as well as for optimization of pharmacotherapy with already registered pharmaceutics. Voriconazole and posaconazole are broad-spectrum, new generation, triazole antifungal agents. The drugs are used in the pharmacotherapy of invasive aspergillosis,

Keywords: clinical pharmacology; cytochrome P-450 enzyme system; drug monitoring; posaconazole; voriconazole

Conflict of interest statement

The authors declare no conflict of interest.

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