Display options
Share it on

Clin Ophthalmol. 2017 Apr 07;11:657-668. doi: 10.2147/OPTH.S101386. eCollection 2017.

Patient selection for corneal collagen cross-linking: an updated review.

Clinical ophthalmology (Auckland, N.Z.)

Virgilio Galvis, Alejandro Tello, Alvaro I Ortiz, Luis C Escaf

Affiliations

  1. Centro Oftalmológico Virgilio Galvis, Floridablanca.
  2. Department of Ophthalmology, Faculty of Health Sciences, Universidad Autónoma de Bucaramanga, Bucaramanga.
  3. Department of Ophthalmology, Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Santander, Colombia.

PMID: 28435217 PMCID: PMC5391157 DOI: 10.2147/OPTH.S101386

Abstract

Corneal cross-linking (CXL) is an option that in the last decade has demonstrated its efficacy and safety in halting the progression of keratoconus (KCN) and other corneal ectasias. Its indication has been extended beyond the classic definition that required evidence of KCN progression, especially in the presence of some risk factors for a possible progression (particularly the younger age). However, the results can be still somewhat variable today. There are several protocols, each with its own advantages and disadvantages. Some predictors of CXL outcome have been identified. We will review the current knowledge on patient selection for CXL, its indications, and options in special cases (such as thin corneas).

Keywords: cornea; corneal collagen cross-linking; cross-linking; keratoconus; keratoectasia

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

References

  1. J Ophthalmic Vis Res. 2015 Jan-Mar;10(1):77-80 - PubMed
  2. Optom Vis Sci. 1997 Mar;74(3):147-51 - PubMed
  3. Biomed Res Int. 2014;2014:619398 - PubMed
  4. Am J Ophthalmol. 2015 Aug;160(2):243-9 - PubMed
  5. Cont Lens Anterior Eye. 2007 Sep;30(4):223-32 - PubMed
  6. J Refract Surg. 2012 Oct;28(10):706-13 - PubMed
  7. Eur J Ophthalmol. 2016 Dec 6;:0 - PubMed
  8. Biomed Res Int. 2014;2014:140461 - PubMed
  9. Br J Ophthalmol. 2011 Nov;95(11):1519-24 - PubMed
  10. J Cataract Refract Surg. 2012 Jun;38(6):1000-5 - PubMed
  11. J Ophthalmol. 2015;2015:690961 - PubMed
  12. Open Ophthalmol J. 2013 Jul 17;7:30-3 - PubMed
  13. Am J Ophthalmol. 2014 Mar;157(3):519-25.e1-2 - PubMed
  14. Invest Ophthalmol Vis Sci. 2006 Feb;47(2):489-500 - PubMed
  15. J Cataract Refract Surg. 2003 Sep;29(9):1780-5 - PubMed
  16. Surv Ophthalmol. 2015 Nov-Dec;60(6):509-23 - PubMed
  17. Am J Ophthalmol. 2012 Jan;153(1):24-8 - PubMed
  18. J Cataract Refract Surg. 2008 May;34(5):796-801 - PubMed
  19. J Cataract Refract Surg. 2009 Mar;35(3):588-9 - PubMed
  20. J Cataract Refract Surg. 2012 Mar;38(3):485-94 - PubMed
  21. J Refract Surg. 2016 Apr;32(4):218-22 - PubMed
  22. Cont Lens Anterior Eye. 2010 Aug;33(4):157-66; quiz 205 - PubMed
  23. Arch Soc Esp Oftalmol. 2017 Apr;92 (4):166-174 - PubMed
  24. Cornea. 2016 Jul;35(7):954-8 - PubMed
  25. Eye Vis (Lond). 2016 Apr 19;3:11 - PubMed
  26. Sci Rep. 2015 Sep 25;5:14425 - PubMed
  27. Cornea. 2012 Mar;31(3):227-31 - PubMed
  28. J Cataract Refract Surg. 2009 Apr;35(4):621-4 - PubMed
  29. Optom Vis Sci. 2005 May;82(5):405-15 - PubMed
  30. Biochim Biophys Acta. 1992 Mar 20;1138(3):222-8 - PubMed
  31. Optom Vis Sci. 1998 Dec;75(12):887-96 - PubMed
  32. J Refract Surg. 2012 Nov;28(11):793-9 - PubMed
  33. J Pediatr Ophthalmol Strabismus. 2011 Jun 21;48 Online:e26-9 - PubMed
  34. Cornea. 2008 Dec;27(10):1109-13 - PubMed
  35. Oman J Ophthalmol. 2015 May-Aug;8(2):86-91 - PubMed
  36. J Cataract Refract Surg. 2010 Jan;36(1):186-8; author reply 188-9 - PubMed
  37. J Ophthalmol. 2014;2014:604731 - PubMed
  38. Clin Ophthalmol. 2012;6:97-101 - PubMed
  39. Pak J Med Sci. 2016 Jul-Aug;32(4):965-8 - PubMed
  40. J Cataract Refract Surg. 2015 Jun;41(6):1336-7 - PubMed
  41. Ophthalmologica. 2014;232(1):10-27 - PubMed
  42. Klin Monbl Augenheilkd. 2015 Dec;232(12):1392-6 - PubMed
  43. Ocul Surf. 2014 Jul;12(3):202-14 - PubMed
  44. Clin Exp Ophthalmol. 2004 Apr;32(2):211-7 - PubMed
  45. Invest Ophthalmol Vis Sci. 2012 Apr 30;53(4):2360-7 - PubMed
  46. Eye (Lond). 2015 Jan;29(1):15-29 - PubMed
  47. Int Ophthalmol. 2017 Apr;37(2):341-348 - PubMed
  48. J Refract Surg. 2016 Mar;32(3):206-8 - PubMed
  49. Transl Vis Sci Technol. 2013 Nov;2(7):6 - PubMed
  50. Invest Ophthalmol Vis Sci. 2013 Feb 01;54(2):1176-80 - PubMed
  51. J Ophthalmol. 2011;2011:869015 - PubMed
  52. Cochrane Database Syst Rev. 2015 Mar 24;(3):CD010621 - PubMed
  53. J Cataract Refract Surg. 2007 Nov;33(11):1982-4 - PubMed
  54. Cornea. 2007 May;26(4):385-9 - PubMed
  55. J Cataract Refract Surg. 2013 Aug;39(8):1157-63 - PubMed
  56. Semin Ophthalmol. 2015;30(5-6):454-6 - PubMed
  57. Adv Biomed Res. 2014 Nov 29;3:221 - PubMed
  58. Am J Ophthalmol. 2015 Dec;160(6):1154-63 - PubMed
  59. Surv Ophthalmol. 1998 Jan-Feb;42(4):297-319 - PubMed
  60. Int Ophthalmol. 2011 Dec;31(6):513-5 - PubMed
  61. Ocul Surf. 2013 Apr;11(2):93-108 - PubMed
  62. Invest Ophthalmol Vis Sci. 2014 May 02;55(5):2881-4 - PubMed
  63. Ophthalmology. 2009 Mar;116(3):369-78 - PubMed
  64. Acta Ophthalmol. 2016 Nov;94(7):e600-e606 - PubMed
  65. J Ophthalmol. 2014;2014:890823 - PubMed
  66. Optom Vis Sci. 2001 Aug;78(8):599-604 - PubMed
  67. J Cataract Refract Surg. 2015 Apr;41(4):842-72 - PubMed
  68. Invest Ophthalmol Vis Sci. 2012 Feb 23;53(2):927-35 - PubMed
  69. Cornea. 2016 Nov;35(11):e36 - PubMed
  70. Ophthalmology. 2013 Aug;120(8):1515-20 - PubMed
  71. Exp Eye Res. 1998 Jan;66(1):97-103 - PubMed
  72. Cornea. 2007 Apr;26(3):243-5 - PubMed
  73. Cornea. 2011 Aug;30(8):917-9 - PubMed
  74. Exp Eye Res. 2016 Dec;153:51-55 - PubMed
  75. Am J Ophthalmol. 2003 May;135(5):620-7 - PubMed
  76. Eye Contact Lens. 2014 Nov;40(6):331-8 - PubMed
  77. J Cataract Refract Surg. 2013 Aug;39(8):1133-40 - PubMed
  78. J Refract Surg. 2014 Jun;30(6):366-72 - PubMed
  79. Cornea. 2015 Sep;34(9):1157-60 - PubMed
  80. J Cataract Refract Surg. 2009 Aug;35(8):1358-62 - PubMed
  81. J Refract Surg. 2012 Nov;28(11):753-8 - PubMed
  82. J Refract Surg. 2014 Jul;30(7):498-500 - PubMed
  83. J Cataract Refract Surg. 2015 Sep;41(9):1989-96 - PubMed
  84. J Cataract Refract Surg. 2010 Jan;36(1):114-20 - PubMed
  85. J Cataract Refract Surg. 2015 Jan;41(1):41-6 - PubMed
  86. Cornea. 1998 May;17(3):267-77 - PubMed
  87. J Cataract Refract Surg. 2011 Jan;37(1):149-60 - PubMed
  88. J Cataract Refract Surg. 2016 Dec;42(12 ):1826-1835 - PubMed
  89. Ophthalmol Eye Dis. 2016 May 12;8:17-21 - PubMed
  90. Eye Vis (Lond). 2015 Sep 07;2:15 - PubMed
  91. J Refract Surg. 2008 Sep;24(7):S720-5 - PubMed
  92. Eye (Lond). 2015 Jul;29(7):843-59 - PubMed
  93. Int Ophthalmol Clin. 2016 Spring;56(2):127-39 - PubMed
  94. Ophthalmology. 1994 Mar;101(3):439-47 - PubMed
  95. J Refract Surg. 2016 May 1;32(5):326-31 - PubMed
  96. J Cataract Refract Surg. 2013 Aug;39(8):1141-5 - PubMed
  97. Cornea. 2013 May;32(5):583-90 - PubMed
  98. Am J Ophthalmol. 2009 May;147(5):774-8, 778.e1 - PubMed
  99. Int Ophthalmol. 2016 Aug;36(4):585-90 - PubMed
  100. Clin Ophthalmol. 2016 Apr 20;10:713-20 - PubMed
  101. Am J Ophthalmol. 2010 Apr;149(4):585-93 - PubMed
  102. Middle East Afr J Ophthalmol. 2015 Jul-Sep;22(3):389-92 - PubMed
  103. Invest Ophthalmol Vis Sci. 2011 Jun 17;52(7):4324-9 - PubMed
  104. Ophthalmology. 2014 Apr;121(4):812-21 - PubMed
  105. Eye (Lond). 2014 Jan;28(1):41-6 - PubMed
  106. Cornea. 2015 Apr;34(4):359-69 - PubMed
  107. Case Rep Ophthalmol Med. 2015;2015:840687 - PubMed
  108. Cornea. 2010 Jan;29(1):65-72 - PubMed
  109. Invest Ophthalmol Vis Sci. 2013 Feb 19;54(2):1418-25 - PubMed
  110. Am J Ophthalmol. 2015 Oct;160(4):654-662.e1 - PubMed
  111. JAMA Ophthalmol. 2015 Nov;133(11):1254-60 - PubMed
  112. Methods Enzymol. 1990;186:485-502 - PubMed
  113. J Cataract Refract Surg. 2009 Mar;35(3):540-6 - PubMed
  114. Cornea. 2016 Mar;35(3):350-4 - PubMed
  115. Ocul Surf. 2013 Apr;11(2):65-74 - PubMed

Publication Types