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Agarwal R, Shruthi R, Radhakrishnan G, et al. Evaluation of Dehydroepiandrosterone Supplementation on Diminished Ovarian Reserve: A Randomized, Double-Blinded, Placebo-Controlled Study. J Obstet Gynaecol India. 2016;67(2):137-142doi: 10.1007/s13224-016-0941-8.
Agarwal, R., Shruthi, R., Radhakrishnan, G., & Singh, A. (2017). Evaluation of Dehydroepiandrosterone Supplementation on Diminished Ovarian Reserve: A Randomized, Double-Blinded, Placebo-Controlled Study. Journal of obstetrics and gynaecology of India, 67(2), 137-142. https://doi.org/10.1007/s13224-016-0941-8
Agarwal, Rachna, et al. "Evaluation of Dehydroepiandrosterone Supplementation on Diminished Ovarian Reserve: A Randomized, Double-Blinded, Placebo-Controlled Study." Journal of obstetrics and gynaecology of India vol. 67,2 (2017): 137-142. doi: https://doi.org/10.1007/s13224-016-0941-8
Agarwal R, Shruthi R, Radhakrishnan G, Singh A. Evaluation of Dehydroepiandrosterone Supplementation on Diminished Ovarian Reserve: A Randomized, Double-Blinded, Placebo-Controlled Study. J Obstet Gynaecol India. 2017 Apr;67(2):137-142. doi: 10.1007/s13224-016-0941-8. Epub 2016 Sep 19. PMID: 28405122; PMCID: PMC5371526.
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J Obstet Gynaecol India. 2017 Apr;67(2):137-142. doi: 10.1007/s13224-016-0941-8. Epub 2016 Sep 19.

Evaluation of Dehydroepiandrosterone Supplementation on Diminished Ovarian Reserve: A Randomized, Double-Blinded, Placebo-Controlled Study.

Journal of obstetrics and gynaecology of India

Rachna Agarwal, R Shruthi, Gita Radhakrishnan, Alpana Singh

Affiliations

  1. Department of Obstetrics and Gynaecology, University College of Medical Sciences and Guru Teg Bahadur, Delhi, 110095 India.
  2. 4/103, East End Apartments, Mayur Vihar Ph-1 Ext., Delhi, 110096 India.

PMID: 28405122 PMCID: PMC5371526 DOI: 10.1007/s13224-016-0941-8

Abstract

INTRODUCTION: We conducted a randomized, double-blinded, placebo-controlled study, to evaluate the effect of dehydroepiandrosterone (DHEA), on diminished ovarian reserve (DOR).

MATERIALS AND METHODS: Twenty patients with DOR received DHEA (oral 25 mg three times a day). Post-supplementation 12 weeks, D2/3 age-specific follicle-stimulating hormone (FSH), anti-mullerian hormone (AMH) levels, and antral follicle count (AFC), were repeated to evaluate response. Spontaneous pregnancy rates and regularization of menstrual cycles were also studied as secondary outcome.

RESULTS: Predominant risk factors were age >35 years (28 %) and poor responders to ovarian stimulation (23 %). There was significant improvement of AMH levels (1.15 ± 1.49 vs. 1.53 ± 1.62) found before and after supplementation in the DHEA group. When the AMH values between DHEA and placebo group were compared, pre- and post-supplementation, no significant difference was found. There was decrease in FSH levels and increase in AFC value post-supplementation in both DHEA and placebo groups which was not statically significant. DHEA supplementation benefited clinically, as evidenced by the improvement in the menstrual abnormality spontaneous conception in two cases each.

CONCLUSIONS: A significant improvement in AMH levels pre- and post-supplementation of DHEA was noted. The same was not seen for FSH and AFC values.

Keywords: Anti-mullerian hormone; Antral follicle count; Dehydroepiandrosterone; Diminished ovarian reserve; FSH

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