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La Vignera S, Condorelli RA, Mongioi LM, et al. Chronic Administration of Tadalafil Improves the Symptoms of Patients with Amicrobic MAGI: An Open Study. Int J Endocrinol. 2017;2017:3848545doi: 10.1155/2017/3848545.
La Vignera, S., Condorelli, R. A., Mongioi, L. M., & Calogero, A. E. (2017). Chronic Administration of Tadalafil Improves the Symptoms of Patients with Amicrobic MAGI: An Open Study. International journal of endocrinology, 20173848545. https://doi.org/10.1155/2017/3848545
La Vignera, Sandro, et al. "Chronic Administration of Tadalafil Improves the Symptoms of Patients with Amicrobic MAGI: An Open Study." International journal of endocrinology vol. 2017 (2017): 3848545. doi: https://doi.org/10.1155/2017/3848545
La Vignera S, Condorelli RA, Mongioi LM, Calogero AE. Chronic Administration of Tadalafil Improves the Symptoms of Patients with Amicrobic MAGI: An Open Study. Int J Endocrinol. 2017;2017:3848545. doi: 10.1155/2017/3848545. Epub 2017 Mar 30. PMID: 28465683; PMCID: PMC5390646.
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Int J Endocrinol. 2017;2017:3848545. doi: 10.1155/2017/3848545. Epub 2017 Mar 30.

Chronic Administration of Tadalafil Improves the Symptoms of Patients with Amicrobic MAGI: An Open Study.

International journal of endocrinology

Sandro La Vignera, Rosita A Condorelli, Laura M Mongioi, Aldo E Calogero

Affiliations

  1. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

PMID: 28465683 PMCID: PMC5390646 DOI: 10.1155/2017/3848545

Abstract

Aim of this study was to evaluate the effects of pharmacological treatment with Tadalafil 5 mg daily on symptoms and quality of sperm parameters in selected patients with amicrobic MAGI (male accessory gland inflammation). 120 patients with amicrobic MAGI (mean age 27.0 ± 6.0 years) with mild-moderate ED (erectile dysfunction) according to IIEF-5 (International Index of Erectile Function 5 Items) scores underwent pharmacological treatment with Tadalafil 5 mg daily for six months. Before and after treatment these patients were evaluated through IIEF-5, semen analysis (according to WHO Criteria, 2010), SI-MAGI (Structured Interview about Male Accessory Gland Inflammation), and ultrasound evaluation. Patients with PVE (prostate-vesciculo-epididymitis) showed a significant increase in the percentage of spermatozoa with total (16.0 ± 8.0 versus 30.0 ± 6.0%) and progressive motility (8.00 ± 10.0 versus 25.0 ± 6.00%). It was a significant reduction of the number of patients with complicated ultrasound forms (30.0 versus 52.0) and a significant increase of the number of patients with uncomplicated ultrasound form (90.0 versus 68.0). Finally, there was a significant reduction in the percentage of patients with alterations of sexual function different from DE, such as premature ejaculation (4.00 versus 8.00%), painful ejaculation (4.00 versus 10.0%), delayed ejaculation (12.50 versus 8.00%), and decreased libido (10.0 versus 25.0%).

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