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Hutchinson JH, Rowbottom MW, Lonergan D, et al. Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS Med Chem Lett. 2017;8(4):423-427doi: 10.1021/acsmedchemlett.7b00014.
Hutchinson, J. H., Rowbottom, M. W., Lonergan, D., Darlington, J., Prodanovich, P., King, C. D., Evans, J. F., & Bain, G. (2017). Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS medicinal chemistry letters, 8(4), 423-427. https://doi.org/10.1021/acsmedchemlett.7b00014
Hutchinson, John H, et al. "Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX." ACS medicinal chemistry letters vol. 8,4 (2017): 423-427. doi: https://doi.org/10.1021/acsmedchemlett.7b00014
Hutchinson JH, Rowbottom MW, Lonergan D, Darlington J, Prodanovich P, King CD, Evans JF, Bain G. Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS Med Chem Lett. 2017 Mar 01;8(4):423-427. doi: 10.1021/acsmedchemlett.7b00014. eCollection 2017 Apr 13. PMID: 28435530; PMCID: PMC5392766.
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ACS Med Chem Lett. 2017 Mar 01;8(4):423-427. doi: 10.1021/acsmedchemlett.7b00014. eCollection 2017 Apr 13.

Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.

ACS medicinal chemistry letters

John H Hutchinson, Martin W Rowbottom, David Lonergan, Janice Darlington, Pat Prodanovich, Christopher D King, Jilly F Evans, Gretchen Bain

Affiliations

  1. PharmAkea Inc., 3030 Bunker Hill Street, Suite 300, San Diego, California 92109, United States.

PMID: 28435530 PMCID: PMC5392766 DOI: 10.1021/acsmedchemlett.7b00014

Abstract

Two series of novel LOXL2 enzyme inhibitors are described: benzylamines substituted with electron withdrawing groups at the

Keywords: (2-chloropyridin-4-yl)methanamine; LOXL2; fibrosis; inhibitor; lysyl oxidase-like 2

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