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Clin Transl Immunology. 2016 Dec 30;5(12):e123. doi: 10.1038/cti.2016.84. eCollection 2016 Dec.

The three Rs: Recruitment, Retention and Residence of leukocytes in the liver.

Clinical & translational immunology

Hayley A McNamara, Ian A Cockburn

Affiliations

  1. Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.

PMID: 28435674 PMCID: PMC5384287 DOI: 10.1038/cti.2016.84

Abstract

The composition of leukocytes in the liver is highly distinct from that of the blood and lymphoid organs. In particular, the liver is highly enriched in non-conventional T cells such as natural killer T (NKT) cells, γδ T cells and mucosal-associated invariant T cells. In addition, there are significant populations of tissue-resident NK cells (or innate lymphoid cells (ILC1)) and memory CD8

Conflict of interest statement

The authors declare no conflict of interest.

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