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Iacopo F, Lorenzo C, Calogero E, et al. Review in Translational Cardiology: MicroRNAs and Myocardial Fibrosis in Aortic Valve Stenosis, a Deep Insight on Left Ventricular Remodeling. J Cardiovasc Echogr. 2016;26(4):109-114doi: 10.4103/2211-4122.192132.
Iacopo, F., Lorenzo, C., Calogero, E., Matteo, P., Riccardo, P. N., Veronica, S., Valentina, B., Riccardo, L., Cristian, S., Maria, M. C., & Vitantonio, D. B. (2016). Review in Translational Cardiology: MicroRNAs and Myocardial Fibrosis in Aortic Valve Stenosis, a Deep Insight on Left Ventricular Remodeling. Journal of cardiovascular echography, 26(4), 109-114. https://doi.org/10.4103/2211-4122.192132
Iacopo, Fabiani, et al. "Review in Translational Cardiology: MicroRNAs and Myocardial Fibrosis in Aortic Valve Stenosis, a Deep Insight on Left Ventricular Remodeling." Journal of cardiovascular echography vol. 26,4 (2016): 109-114. doi: https://doi.org/10.4103/2211-4122.192132
Iacopo F, Lorenzo C, Calogero E, Matteo P, Riccardo PN, Veronica S, Valentina B, Riccardo L, Cristian S, Maria MC, Vitantonio DB. Review in Translational Cardiology: MicroRNAs and Myocardial Fibrosis in Aortic Valve Stenosis, a Deep Insight on Left Ventricular Remodeling. J Cardiovasc Echogr. 2016 Oct-Dec;26(4):109-114. doi: 10.4103/2211-4122.192132. PMID: 28465975; PMCID: PMC5224662.
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J Cardiovasc Echogr. 2016 Oct-Dec;26(4):109-114. doi: 10.4103/2211-4122.192132.

Review in Translational Cardiology: MicroRNAs and Myocardial Fibrosis in Aortic Valve Stenosis, a Deep Insight on Left Ventricular Remodeling.

Journal of cardiovascular echography

Fabiani Iacopo, Conte Lorenzo, Enrico Calogero, Passiatore Matteo, Pugliese Nicola Riccardo, Santini Veronica, Barletta Valentina, Liga Riccardo, Scatena Cristian, Mazzanti Chiara Maria, Di Bello Vitantonio

Affiliations

  1. Department of Surgical, Medical, Molecular Pathology and Critical Area, Cisanello Hospital, University of Pisa, Pisa, Italy.
  2. Fondazione Pisana per la Scienza, 56100, Pisa, Italy.

PMID: 28465975 PMCID: PMC5224662 DOI: 10.4103/2211-4122.192132

Abstract

MicroRNAs (miRNAs) are a huge class of noncoding RNAs that regulate protein-encoding genes (degradation/inhibition of translation). miRNAs are nowadays recognized as regulators of biological processes underneath cardiovascular disorders including hypertrophy, ischemia, arrhythmias, and valvular disease. In particular, circulating miRNAs are promising biomarkers of pathology. This review gives an overview of studies in aortic valve stenosis (AS), exclusively considering myocardial remodeling processes. We searched through literature (till September 2016), all studies and reviews involving miRNAs and AS (myocardial compartment). Although at the beginning of a new era, clear evidences exist on the potential diagnostic and prognostic implementation of miRNAs in the clinical setting. In particular, for AS, miRNAs are modulators of myocardial remodeling and hypertrophy. In our experience, here presented in summary, the principal findings of our research were a confirm of the pathophysiological role in AS of miRNA-21, in particular, the interdependence between textural miRNA-21 and fibrogenic stimulus induced by an abnormal left ventricular pressure overload. Moreover, circulating miRNA-21 (biomarker) levels are able to reflect the presence of significant myocardial fibrosis (MF). Thus, the combined evaluation of miRNA-21, a marker of MF, and hypertrophy, together with advanced echocardiographic imaging (two-dimensional speckle tracking), could fulfill many existing gaps, renewing older guidelines paradigms, also allowing a better risk prognostic and diagnostic strategies.

Keywords: Aortic stenosis; global longitudinal strain; microRNA; myocardial fibrosis; ventricular remodeling

Conflict of interest statement

There are no conflicts of interest.

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