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Velissaris D, Pantzaris N, Koniari I, et al. C-Reactive Protein and Frailty in the Elderly: A Literature Review. J Clin Med Res. 2017;9(6):461-465doi: 10.14740/jocmr2959w.
Velissaris, D., Pantzaris, N., Koniari, I., Koutsogiannis, N., Karamouzos, V., Kotroni, I., Skroumpelou, A., & Ellul, J. (2017). C-Reactive Protein and Frailty in the Elderly: A Literature Review. Journal of clinical medicine research, 9(6), 461-465. https://doi.org/10.14740/jocmr2959w
Velissaris, Dimitrios, et al. "C-Reactive Protein and Frailty in the Elderly: A Literature Review." Journal of clinical medicine research vol. 9,6 (2017): 461-465. doi: https://doi.org/10.14740/jocmr2959w
Velissaris D, Pantzaris N, Koniari I, Koutsogiannis N, Karamouzos V, Kotroni I, Skroumpelou A, Ellul J. C-Reactive Protein and Frailty in the Elderly: A Literature Review. J Clin Med Res. 2017 Jun;9(6):461-465. doi: 10.14740/jocmr2959w. Epub 2017 Apr 26. PMID: 28496545; PMCID: PMC5412518.
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J Clin Med Res. 2017 Jun;9(6):461-465. doi: 10.14740/jocmr2959w. Epub 2017 Apr 26.

C-Reactive Protein and Frailty in the Elderly: A Literature Review.

Journal of clinical medicine research

Dimitrios Velissaris, Nikolaos Pantzaris, Ioanna Koniari, Nikolaos Koutsogiannis, Vasilios Karamouzos, Ioanna Kotroni, Anastasia Skroumpelou, John Ellul

Affiliations

  1. Internal Medicine Department, University Hospital of Patras, Greece.
  2. University Hospital of Patras, Greece.
  3. Department of Cardiology, University Hospital of Patras, Greece.
  4. Intensive Care Unit, University Hospital of Patras, Greece.
  5. Coronary Care Unit, University Hospital of Patras, Greece.
  6. Department of Neurology, University Hospital of Patras, Greece.

PMID: 28496545 PMCID: PMC5412518 DOI: 10.14740/jocmr2959w

Abstract

Chronic inflammation is a well-established background process in many age-related diseases. Many recent studies investigate the use of various inflammatory biomarkers such as C-reactive protein (CRP), interleukin-6, and interleukin-1 as predictors of physical and cognitive performance among elders. The phenotype of frailty has also been associated with underlying inflammatory mechanisms. The aim of this article was to review the literature referring to the correlation of CRP serum levels and frailty in older individuals. We tried to identify all relevant publications regarding the relation of CRP as an index of frailty in the elderly and its potential use. Although many studies in the recent medical literature positively associate serum CRP levels and frailty in older individuals, some do not, and some raise some interesting questions and set the basis for future studies. The association of CRP and frailty in elder patients should be considered when clinicians interpret inflammatory biomarkers in various clinical settings in such patients. Well-designed, prospective clinical trials are warranted to better assess the role and pathophysiology of frailty in the elderly and its mechanisms as also the exact role of CRP as an inflammatory marker and as a prognostic index in this syndrome.

Keywords: C-reactive protein; Elderly; Frailty

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