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Brown TJ, Gentry C, Hammer ST, et al. Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation. ACG Case Rep J. 2017;4:e48doi: 10.14309/crj.2017.48.
Brown, T. J., Gentry, C., Hammer, S. T., Hwang, C. S., Vusirikala, M., Patel, P. A., Matevosyan, K., Tujios, S. R., Mufti, A. R., & Collins, R. H. (2017). Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation. ACG case reports journal, 4e48. https://doi.org/10.14309/crj.2017.48
Brown, Timothy J, et al. "Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation." ACG case reports journal vol. 4 (2017): e48. doi: https://doi.org/10.14309/crj.2017.48
Brown TJ, Gentry C, Hammer ST, Hwang CS, Vusirikala M, Patel PA, Matevosyan K, Tujios SR, Mufti AR, Collins RH. Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation. ACG Case Rep J. 2017 Mar 29;4:e48. doi: 10.14309/crj.2017.48. eCollection 2017. PMID: 28377936; PMCID: PMC5371721.
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ACG Case Rep J. 2017 Mar 29;4:e48. doi: 10.14309/crj.2017.48. eCollection 2017.

Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation.

ACG case reports journal

Timothy J Brown, Cathy Gentry, Suntrea T G Hammer, Christine S Hwang, Madhuri Vusirikala, Prapti A Patel, Karén Matevosyan, Shannan R Tujios, Arjmand R Mufti, Robert H Collins

Affiliations

  1. Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
  2. University of Texas Southwestern Medical School, Dallas, TX.
  3. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
  4. Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX.
  5. Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX.
  6. Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX.

PMID: 28377936 PMCID: PMC5371721 DOI: 10.14309/crj.2017.48

Abstract

A 48-year-old man with hepatitis C virus (HCV) cirrhosis complicated by hepatocellular carcinoma underwent liver transplantation. His course was complicated by fever, diarrhea, abdominal pain, and pancytopenia. He developed a diffuse erythematous rash, which progressed to erythroderma. Biopsies of the colon and skin were consistent with acute graft-versus-host disease. Donor-derived lymphocytes were present in the peripheral blood. The patient was treated with corticosteroids and cyclosporine; however, he had minimal response to intensive immunosuppressive therapy. Extracorporeal photopheresis was initiated as a salvage therapy. He had a dramatic response, and his rash, diarrhea, and pancytopenia resolved. He is maintained on minimal immunosuppression 24 months later.

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