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Salles A, Krawczyk MDC, Blake M, et al. Requirement of NF-kappa B Activation in Different Mice Brain Areas during Long-Term Memory Consolidation in Two Contextual One-Trial Tasks with Opposing Valences. Front Mol Neurosci. 2017;10:104doi: 10.3389/fnmol.2017.00104.
Salles, A., Krawczyk, M. D. C., Blake, M., Romano, A., Boccia, M. M., & Freudenthal, R. (2017). Requirement of NF-kappa B Activation in Different Mice Brain Areas during Long-Term Memory Consolidation in Two Contextual One-Trial Tasks with Opposing Valences. Frontiers in molecular neuroscience, 10104. https://doi.org/10.3389/fnmol.2017.00104
Salles, Angeles, et al. "Requirement of NF-kappa B Activation in Different Mice Brain Areas during Long-Term Memory Consolidation in Two Contextual One-Trial Tasks with Opposing Valences." Frontiers in molecular neuroscience vol. 10 (2017): 104. doi: https://doi.org/10.3389/fnmol.2017.00104
Salles A, Krawczyk MDC, Blake M, Romano A, Boccia MM, Freudenthal R. Requirement of NF-kappa B Activation in Different Mice Brain Areas during Long-Term Memory Consolidation in Two Contextual One-Trial Tasks with Opposing Valences. Front Mol Neurosci. 2017 Apr 07;10:104. doi: 10.3389/fnmol.2017.00104. eCollection 2017. PMID: 28439227; PMCID: PMC5383659.
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Front Mol Neurosci. 2017 Apr 07;10:104. doi: 10.3389/fnmol.2017.00104. eCollection 2017.

Requirement of NF-kappa B Activation in Different Mice Brain Areas during Long-Term Memory Consolidation in Two Contextual One-Trial Tasks with Opposing Valences.

Frontiers in molecular neuroscience

Angeles Salles, Maria Del C Krawczyk, Mariano Blake, Arturo Romano, Mariano M Boccia, Ramiro Freudenthal

Affiliations

  1. Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos AiresBuenos Aires, Argentina.
  2. Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), CONICET-Universidad de Buenos AiresBuenos Aires, Argentina.
  3. Laboratorio de Neurofarmacología de los Procesos de Memoria, Cátedra de Farmacología, Fac. Farmacia y Bioquímica, Universidad de Buenos Aires/CONICETBuenos Aires, Argentina.
  4. Departamento de Fisiología, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Facultad de Medicina, Universidad de Buenos Aires, CONICETBuenos Aires, Argentina.

PMID: 28439227 PMCID: PMC5383659 DOI: 10.3389/fnmol.2017.00104

Abstract

NF-kappa B is a transcription factor whose activation has been shown to be necessary for long-term memory consolidation in several species. NF-kappa B is activated and translocates to the nucleus of cells in a specific temporal window during consolidation. Our work focuses on a one trial learning tasks associated to the inhibitory avoidance (IA) setting. Mice were trained either receiving or not a footshock when entering a dark compartment (aversive vs. appetitive learning). Regardless of training condition (appetitive or aversive), latencies to step-through during testing were significantly different to those measured during training. Additionally, these testing latencies were also different from those of a control group that only received a shock unrelated to context. Moreover, nuclear NF-kappa B DNA-binding activity was augmented in the aversive and the appetitive tasks when compared with control and naïve animals. NF-kappa B inhibition by Sulfasalazine injected either in the Hippocampus, Amygdala or Nucleus accumbens immediately after training was able to impair retention in both training versions. Our results suggest that NF-kappa B is a critical molecular step, in different brain areas on memory consolidation. This was the case for both the IA task and also the modified version of the same task where the footshock was omitted during training. This work aims to further investigate how appetitive and aversive memories are consolidated.

Keywords: NF-kappa B; amygdala; hippocampus; inhibitory avoidance learning; nucleus accumbens; one-trial learning

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