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Front Cell Neurosci. 2017 Apr 19;11:103. doi: 10.3389/fncel.2017.00103. eCollection 2017.

Intracellular Fibroblast Growth Factor 14: Emerging Risk Factor for Brain Disorders.

Frontiers in cellular neuroscience

Jessica Di Re, Paul A Wadsworth, Fernanda Laezza

Affiliations

  1. Neuroscience Graduate Program, University of Texas Medical BranchGalveston, TX, USA.
  2. Department of Pharmacology and Toxicology, University of Texas Medical BranchGalveston, TX, USA.
  3. Biochemistry and Molecular Biology Graduate Program, The University of Texas Medical BranchGalveston, TX, USA.
  4. Mitchell Center for Neurodegenerative Diseases, The University of Texas Medical BranchGalveston, TX, USA.
  5. Center for Addiction Research, The University of Texas Medical BranchGalveston, TX, USA.

PMID: 28469558 PMCID: PMC5396478 DOI: 10.3389/fncel.2017.00103

Abstract

The finely tuned regulation of neuronal firing relies on the integrity of ion channel macromolecular complexes. Minimal disturbances of these tightly regulated networks can lead to persistent maladaptive plasticity of brain circuitry. The intracellular fibroblast growth factor 14 (FGF14) belongs to the nexus of proteins interacting with voltage-gated Na+ (Na

Keywords: biological psychiatry; intracellular signaling; neuronal excitability; protein-protein interactions

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