Display options
Cite
Ekmekciu I, von Klitzing E, Fiebiger U, et al. Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in Mice. Front Immunol. 2017;8:397doi: 10.3389/fimmu.2017.00397.
Ekmekciu, I., von Klitzing, E., Fiebiger, U., Escher, U., Neumann, C., Bacher, P., Scheffold, A., Kühl, A. A., Bereswill, S., & Heimesaat, M. M. (2017). Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in Mice. Frontiers in immunology, 8397. https://doi.org/10.3389/fimmu.2017.00397
Ekmekciu, Ira, et al. "Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in Mice." Frontiers in immunology vol. 8 (2017): 397. doi: https://doi.org/10.3389/fimmu.2017.00397
Ekmekciu I, von Klitzing E, Fiebiger U, Escher U, Neumann C, Bacher P, Scheffold A, Kühl AA, Bereswill S, Heimesaat MM. Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in Mice. Front Immunol. 2017 Apr 19;8:397. doi: 10.3389/fimmu.2017.00397. eCollection 2017. PMID: 28469619; PMCID: PMC5395657.
Copy Download .nbib Format: NLM
Share it on

Front Immunol. 2017 Apr 19;8:397. doi: 10.3389/fimmu.2017.00397. eCollection 2017.

Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in Mice.

Frontiers in immunology

Ira Ekmekciu, Eliane von Klitzing, Ulrike Fiebiger, Ulrike Escher, Christian Neumann, Petra Bacher, Alexander Scheffold, Anja A Kühl, Stefan Bereswill, Markus M Heimesaat

Affiliations

  1. Department of Microbiology and Hygiene, Charité - University Medicine Berlin, Berlin, Germany.
  2. Department of Cellular Immunology, Clinic for Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany.
  3. German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany.
  4. Department of Medicine I for Gastroenterology, Infectious Diseases and Rheumatology, Research Center ImmunoSciences (RCIS), Charité - University Medicine Berlin, Berlin, Germany.

PMID: 28469619 PMCID: PMC5395657 DOI: 10.3389/fimmu.2017.00397

Abstract

Compelling evidence demonstrates the pivotal role of the commensal intestinal microbiota in host physiology and the detrimental effects of its perturbations following antibiotic treatment. Aim of this study was to investigate the impact of antibiotics induced depletion and subsequent restoration of the intestinal microbiota composition on the murine mucosal and systemic immunity. To address this, conventional C57BL/6j mice were subjected to broad-spectrum antibiotic treatment for 8 weeks. Restoration of the intestinal microbiota by peroral fecal microbiota transplantation (FMT) led to reestablishment of small intestinal CD4

Keywords: antibiotics; bacterial recolonization; fecal microbiota transplantation; innate and adaptive immunity; microbiota; mucosal and systemic immune responses; secondary abiotic (gnotobiotic) mice

References

  1. Infect Immun. 2009 Jul;77(7):2741-53 - PubMed
  2. Pharmacol Ther. 2008 Mar;117(3):393-405 - PubMed
  3. Clin Med Res. 2005 Aug;3(3):166-75 - PubMed
  4. PLoS One. 2011;6(6):e20953 - PubMed
  5. Nature. 2008 Nov 27;456(7221):507-10 - PubMed
  6. Inflamm Bowel Dis. 2016 Oct;22(10):2402-9 - PubMed
  7. Immunol Cell Biol. 2010 Jan;88(1):99-102 - PubMed
  8. Bioessays. 2014 Oct;36(10):933-9 - PubMed
  9. Front Cell Infect Microbiol. 2014 Jun 10;4:77 - PubMed
  10. Curr Opin Rheumatol. 2011 Jul;23(4):372-6 - PubMed
  11. Lancet Infect Dis. 2003 Jun;3(6):359-71 - PubMed
  12. Clin Microbiol Rev. 2010 Jul;23(3):590-615 - PubMed
  13. Antimicrob Agents Chemother. 2000 Nov;44(11):3169-73 - PubMed
  14. Nat Rev Immunol. 2004 Jun;4(6):478-85 - PubMed
  15. Am J Gastroenterol. 2012 Jul;107(7):1079-87 - PubMed
  16. Curr Opin Biotechnol. 2013 Apr;24(2):160-8 - PubMed
  17. Clin Microbiol Infect. 2002 Jan;8(1):26-30 - PubMed
  18. J Clin Invest. 2010 Dec;120(12):4332-41 - PubMed
  19. Eur J Microbiol Immunol (Bp). 2016 Dec 01;6(4):253-271 - PubMed
  20. Gut. 2006 Feb;55(2):205-11 - PubMed
  21. Nat Rev Immunol. 2009 May;9(5):313-23 - PubMed
  22. Eur J Microbiol Immunol (Bp). 2015 Oct 21;5(4):256-67 - PubMed
  23. Cell Res. 2014 Jan;24(1):5-6 - PubMed
  24. J Immunol. 2006 Dec 15;177(12):8785-95 - PubMed
  25. Gut. 2014 Sep;63(9):1513-21 - PubMed
  26. Microbes Infect. 2001 Oct;3(12):1021-35 - PubMed
  27. Gut. 2010 Aug;59(8):1079-87 - PubMed
  28. Gut Microbes. 2014;5(5):579-93 - PubMed
  29. Gut. 2015 Nov;64(11):1732-43 - PubMed
  30. J Cell Physiol. 2000 Mar;182(3):311-22 - PubMed
  31. PLoS One. 2009;4(3):e4903 - PubMed
  32. Infect Immun. 2012 Jan;80(1):62-73 - PubMed
  33. Science. 2011 Jan 21;331(6015):337-41 - PubMed
  34. Curr Protoc Immunol. 2012 Nov;Chapter 3:Unit3.19 - PubMed
  35. EMBO Rep. 2012 May 01;13(5):440-7 - PubMed
  36. J Antimicrob Chemother. 2002 Jul;50(1):51-8 - PubMed
  37. PLoS One. 2013 Sep 10;8(9):e74026 - PubMed
  38. Cell Mol Life Sci. 2002 Dec;59(12):2088-96 - PubMed
  39. Cell. 2016 Jan 28;164(3):337-40 - PubMed
  40. Science. 2005 Mar 25;307(5717):1915-20 - PubMed
  41. Nat Med. 2012 Mar 25;18(4):538-46 - PubMed
  42. Gut. 2013 Feb;62(2):220-6 - PubMed
  43. J Clin Gastroenterol. 2010 Sep;44(8):567-70 - PubMed
  44. Eur J Microbiol Immunol (Bp). 2013 Mar;3(1):1-10 - PubMed
  45. J Immunol. 2008 Jan 1;180(1):559-68 - PubMed
  46. Nat Rev Immunol. 2010 Mar;10(3):159-69 - PubMed
  47. Semin Immunol. 2007 Dec;19(6):377-82 - PubMed
  48. Trends Neurosci. 2013 May;36(5):305-12 - PubMed
  49. Euro Surveill. 2009 Aug 27;14(34):null - PubMed
  50. Gut. 2007 Jul;56(7):941-8 - PubMed
  51. Gut. 2009 Jun;58(6):771-6 - PubMed
  52. Eur J Microbiol Immunol (Bp). 2016 Mar 28;6(1):56-66 - PubMed
  53. Nat Rev Immunol. 2010 Oct;10(10):735-44 - PubMed
  54. Cell Host Microbe. 2008 Oct 16;4(4):337-49 - PubMed
  55. PLoS One. 2010 Mar 24;5(3):e9836 - PubMed
  56. Clin Exp Allergy. 2009 Apr;39(4):518-26 - PubMed
  57. Trends Mol Med. 2016 Jun;22(6):458-78 - PubMed
  58. Pediatr Gastroenterol Hepatol Nutr. 2013 Mar;16(1):17-21 - PubMed
  59. Transplant Proc. 2016 Mar;48(2):402-7 - PubMed
  60. Immunity. 2009 Oct 16;31(4):677-89 - PubMed
  61. J Biol Chem. 2008 Sep 5;283(36):24392-9 - PubMed
  62. J Exp Med. 2009 Dec 21;206(13):3047-59 - PubMed
  63. Nature. 2008 Oct 9;455(7214):804-7 - PubMed
  64. ISME J. 2007 May;1(1):56-66 - PubMed
  65. Am J Gastroenterol. 2012 Nov;107(11):1755; author reply p.1755-6 - PubMed
  66. Infect Immun. 2008 Oct;76(10):4726-36 - PubMed
  67. Eur J Microbiol Immunol (Bp). 2015 Nov 17;5(4):333-42 - PubMed
  68. N Engl J Med. 2002 Jan 31;346(5):334-9 - PubMed

Publication Types