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Tékus É, Váczi M, Horváth-Szalai Z, et al. Plasma Actin, Gelsolin and Orosomucoid Levels after Eccentric Exercise. J Hum Kinet. 2017;56:99-108doi: 10.1515/hukin-2017-0027.
Tékus, �. �., Váczi, M., Horváth-Szalai, Z., Ludány, A., Kőszegi, T., & Wilhelm, M. (2017). Plasma Actin, Gelsolin and Orosomucoid Levels after Eccentric Exercise. Journal of human kinetics, 5699-108. https://doi.org/10.1515/hukin-2017-0027
Tékus, Éva, et al. "Plasma Actin, Gelsolin and Orosomucoid Levels after Eccentric Exercise." Journal of human kinetics vol. 56 (2017): 99-108. doi: https://doi.org/10.1515/hukin-2017-0027
Tékus É, Váczi M, Horváth-Szalai Z, Ludány A, Kőszegi T, Wilhelm M. Plasma Actin, Gelsolin and Orosomucoid Levels after Eccentric Exercise. J Hum Kinet. 2017 Mar 15;56:99-108. doi: 10.1515/hukin-2017-0027. eCollection 2017 Feb. PMID: 28469748; PMCID: PMC5384057.
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J Hum Kinet. 2017 Mar 15;56:99-108. doi: 10.1515/hukin-2017-0027. eCollection 2017 Feb.

Plasma Actin, Gelsolin and Orosomucoid Levels after Eccentric Exercise.

Journal of human kinetics

Éva Tékus, Márk Váczi, Zoltán Horváth-Szalai, Andrea Ludány, Tamás Kőszegi, Márta Wilhelm

Affiliations

  1. Institute of Sport Sciences and Physical Education, University of Pécs, Pécs, Hungary.
  2. Doctoral School of Biology and Sportbiology, University of Pécs, Pécs, Hungary.
  3. Institute of Laboratory Medicine, University of Pécs, Pécs, Hungary.
  4. János Szentágothai Research Center, Pécs, Hungary.

PMID: 28469748 PMCID: PMC5384057 DOI: 10.1515/hukin-2017-0027

Abstract

The present study investigated the acute effect of eccentric exercise on blood plasma actin, gelsolin (GSN) and orosomucoid (AGP) levels in untrained and moderately trained individuals, and their correlation with exercise induced muscle damage (EIMD) markers (CK, intensity of muscle soreness and maximal voluntary contraction torque deficit). Healthy physical education students (6 untrained, 12 moderately trained) participated in this research. Actin, GSN, AGP and CK levels were measured in blood plasma at baseline, immediately, 1 h, 6 h and 24 h post-exercise comprising 90 eccentric quadriceps contractions performed on a dynamometer. There was significant time main effect for GSN, AGP, CK and significant difference was found between baseline and the lowest value of post-exercise GSN (p < 0.05), as well as baseline and the highest value of post-exercise AGP (p < 0.05). Relationships were found between GSN levels and other indirect EIMD markers (between all GSN levels at post-exercise and CK activity at 6 h, p < 0.05; GSNMIN and muscle soreness at post-exercise, p < 0.04), GSN and AGP; however, actin did not correlate at any time points with GSN. Actin, GSN, AGP and CK responses after eccentric exercise do not seem sensitive to training status. The plasma actin level is used as an indicator of injury, however, our results suggest that it is not an accurate marker of EIMD, while plasma GSN concentrations show a better relationship with EIMD and the post-exercise inflammatory process. The elevated plasma AGP and the correlation between GSN and AGP seem to be promising for assessment of exercise-induced muscle injury.

Keywords: actin; biomarker; eccentric exercise; exercise; gelsolin; muscle damage

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