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Schoen T, Aeschbacher S, Leuppi JD, et al. Subclinical sleep apnoea and plasma levels of endothelin-1 among young and healthy adults. Open Heart. 2017;4(1):e000523doi: 10.1136/openhrt-2016-000523.
Schoen, T., Aeschbacher, S., Leuppi, J. D., Miedinger, D., Werthmüller, U., Estis, J., Todd, J., Risch, M., Risch, L., & Conen, D. (2017). Subclinical sleep apnoea and plasma levels of endothelin-1 among young and healthy adults. Open heart, 4(1), e000523. https://doi.org/10.1136/openhrt-2016-000523
Schoen, Tobias, et al. "Subclinical sleep apnoea and plasma levels of endothelin-1 among young and healthy adults." Open heart vol. 4,1 (2017): e000523. doi: https://doi.org/10.1136/openhrt-2016-000523
Schoen T, Aeschbacher S, Leuppi JD, Miedinger D, Werthmüller U, Estis J, Todd J, Risch M, Risch L, Conen D. Subclinical sleep apnoea and plasma levels of endothelin-1 among young and healthy adults. Open Heart. 2017 Mar 01;4(1):e000523. doi: 10.1136/openhrt-2016-000523. eCollection 2017. PMID: 28409007; PMCID: PMC5384465.
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Open Heart. 2017 Mar 01;4(1):e000523. doi: 10.1136/openhrt-2016-000523. eCollection 2017.

Subclinical sleep apnoea and plasma levels of endothelin-1 among young and healthy adults.

Open heart

Tobias Schoen, Stefanie Aeschbacher, Joerg D Leuppi, David Miedinger, Ursina Werthmüller, Joel Estis, John Todd, Martin Risch, Lorenz Risch, David Conen

Affiliations

  1. Division of Cardiology, University Hospital Basel, Basel, Switzerland.
  2. Cardiovascular Research Institute Basel, Basel, Switzerland.
  3. Division of Internal Medicine, University Hospital Basel, Basel, Switzerland.
  4. Medical University Clinic of Baselland and Medical Faculty of Basel, Liestal/Basel, Switzerland.
  5. Faculty of Medicine, University of Basel, Basel, Switzerland.
  6. Singulex, Inc, Alameda, California, USA.
  7. Labormedizinisches Zentrum Dr. Risch, Schaan, Liechtenstein.
  8. Division of Laboratory Medicine, Kantonspital Graubünden, Chur, Switzerland.
  9. Division of Clinical Biochemistry, Medical University Innsbruck, Austria.
  10. Private University, Triesen, Liechtenstein.
  11. Cardiology Division, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
  12. Population Health Research Institute, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.

PMID: 28409007 PMCID: PMC5384465 DOI: 10.1136/openhrt-2016-000523

Abstract

OBJECTIVE: Obstructive sleep apnoea (OSA) is a risk factor for vascular disease and other adverse outcomes. These associations may be at least partly due to early endothelin-1 (ET-1)-mediated endothelial dysfunction (ED). Therefore, we assessed the relationships between subclinical sleep apnoea and plasma levels of ET-1.

METHODS: We performed a population-based study among 1255 young and healthy adults aged 25-41 years. Cardiovascular disease, diabetes or a body mass index >35 kg/m

RESULTS: Median age of the cohort was 35 years. Median ET-1 levels were 2.9 (IQR 2.4-3.6) and 2.5 pg/mL (IQR 2.1-3.0) among patients with (n=105; 8%) and without subclinical sleep apnoea (REI 5-14), respectively. After multivariable adjustment, subclinical sleep apnoea remained significantly associated with plasma levels of ET-1 (β=0.13 (95% CI 0.06 to 0.20) p=0.0002 for a REI 5-14; β=0.10 (95% CI 0.03 to 0.16) p=0.003 for an ODI≥5). Every 1% decrease in mean night-time SpO

CONCLUSIONS: In this study of young and healthy adults, we found that participants with subclinical sleep apnoea had elevated plasma ET-1 levels, an association that was due to night-time hypoxaemia. Our results suggest that ED may already be an important consequence of subclinical sleep apnoea.

Keywords: ENDOTHELIN-1; HYPOXEMIA; SLEEP APNEA

Conflict of interest statement

Competing interests: JT and JE are employees of Singulex and hold stock options in Singulex. They are also co-inventors on patents filed in regard to assay methods for measuring endothelin-1 levels.

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