Display options
Share it on

World J Clin Cases. 2017 Apr 16;5(4):134-139. doi: 10.12998/wjcc.v5.i4.134.

Esophageal squamous papilloma lacks clear clinicopathological associations.

World journal of clinical cases

Bilel Jideh, Martin Weltman, Yang Wu, Calvin H Y Chan

Affiliations

  1. Bilel Jideh, Martin Weltman, Yang Wu, Calvin H Y Chan, Department of Gastroenterology and Hepatology, Nepean Hospital, Sydney, NSW 2747, Australia.

PMID: 28470005 PMCID: PMC5395981 DOI: 10.12998/wjcc.v5.i4.134

Abstract

AIM: To determine the prevalence of esophageal squamous papillomas (ESPs) in a tertiary teaching hospital and to assess for any clinical associations, including relations with esophageal squamous cell carcinomas (SCCs).

METHODS: Data from a total of 6962 upper gastrointestinal endoscopies over a five year period were retrospectively obtained and analysed.

RESULTS: ESP was found in sixteen patients (0.23%). Eight (50%) patients had a high body mass index, seven (44%) had history of cigarette smoking. Reflux esophagitis was found in four (25%) patients. All ESPs were solitary with a mean endoscopic size of 3.8 mm and located in the mid to lower esophagus. Human papilloma virus (HPV) was tested in three (19%) patients and was negative. Esophageal SCC was found in seven patients (0.10%) during the same period. None of the specimens were tested for HPV, and none had associated papillomatous changes.

CONCLUSION: ESP is an uncommon tumour with unclear clinical associations and malignant potential.

Keywords: Esophagus; Gastroesophageal reflux disease; Human papilloma virus; Papilloma; Squamous cell carcinoma

Conflict of interest statement

Conflict-of-interest statement: None of the authors have any conflict of interest to declare.

References

  1. Ann Intern Med. 1999 Jun 1;130(11):883-90 - PubMed
  2. Gut. 1990 Jan;31(1):4-10 - PubMed
  3. J Pediatr Gastroenterol Nutr. 1990 Aug;11(2):285-7 - PubMed
  4. Gastroenterology. 1992 Feb;102(2):668-73 - PubMed
  5. Gastrointest Endosc. 1983 May;29(2):104-6 - PubMed
  6. Am J Gastroenterol. 1987 Nov;82(11):1177-9 - PubMed
  7. Head Neck. 2013 May;35(5):747-55 - PubMed
  8. J Gastroenterol Hepatol. 2001 Aug;16(8):857-61 - PubMed
  9. Endoscopy. 1988 Jan;20(1):5-7 - PubMed
  10. Acta Histochem Cytochem. 2006 Mar 2;39(1):23-30 - PubMed
  11. Br J Cancer. 2014 Apr 29;110(9):2369-77 - PubMed
  12. Int J Cancer. 1999 Mar 1;80(5):681-4 - PubMed
  13. Gastroenterology. 1978 May;74(5 Pt 1):910-3 - PubMed
  14. Scand J Gastroenterol. 1991 May;26(5):535-43 - PubMed
  15. Am J Gastroenterol. 1994 Mar;89(3):434-7 - PubMed
  16. J Clin Pathol. 1990 Nov;43(11):909-12 - PubMed
  17. Am J Gastroenterol. 1994 Feb;89(2):245-8 - PubMed
  18. World J Gastrointest Endosc. 2015 Mar 16;7(3):290-4 - PubMed
  19. Aliment Pharmacol Ther. 2014 Feb;39(3):270-81 - PubMed
  20. J Clin Gastroenterol. 1996 Jan;22(1):35-7 - PubMed
  21. Scand J Gastroenterol. 1996 Jan;31(1):10-3 - PubMed
  22. Int J Cancer. 2000 Jun 15;86(6):874-8 - PubMed
  23. Am J Gastroenterol. 1986 Nov;81(11):1059-62 - PubMed
  24. JAMA. 1976 Dec 6;236(23):2655 - PubMed
  25. CMAJ. 2001 Apr 3;164(7):1017-25 - PubMed
  26. Am J Surg Pathol. 1993 Aug;17(8):803-12 - PubMed
  27. Hum Pathol. 1994 May;25(5):536-40 - PubMed
  28. Am J Gastroenterol. 2008 Feb;103(2):292-300 - PubMed
  29. Diagn Histopathol. 1982 Oct-Dec;5(4):291-6 - PubMed

Publication Types