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Fleck O, Fahnøe U, Løvschal KV, et al. Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication. Genes (Basel). 2017;8(5)doi: 10.3390/genes8050128.
Fleck, O., Fahnøe, U., Løvschal, K. V., Gasasira, M. U., Marinova, I. N., Kragelund, B. B., Carr, A. M., Hartsuiker, E., Holmberg, C., & Nielsen, O. (2017). Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication. Genes, 8(5), . https://doi.org/10.3390/genes8050128
Fleck, Oliver, et al. "Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication." Genes vol. 8,5 (2017). doi: https://doi.org/10.3390/genes8050128
Fleck O, Fahnøe U, Løvschal KV, Gasasira MU, Marinova IN, Kragelund BB, Carr AM, Hartsuiker E, Holmberg C, Nielsen O. Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication. Genes (Basel). 2017 Apr 25;8(5). doi: 10.3390/genes8050128. PMID: 28441348; PMCID: PMC5448002.
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Genes (Basel). 2017 Apr 25;8(5). doi: 10.3390/genes8050128.

Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication.

Genes

Oliver Fleck, Ulrik Fahnøe, Katrine Vyff Løvschal, Marie-Fabrice Uwamahoro Gasasira, Irina N Marinova, Birthe B Kragelund, Antony M Carr, Edgar Hartsuiker, Christian Holmberg, Olaf Nielsen

Affiliations

  1. Cell Cycle and Genome Stability Group, Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark. [email protected].
  2. North West Cancer Research Institute, Bangor University, Bangor, Gwynedd LL57 2UW, UK. [email protected].
  3. Cell Cycle and Genome Stability Group, Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark. [email protected].
  4. Cell Cycle and Genome Stability Group, Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark. [email protected].
  5. North West Cancer Research Institute, Bangor University, Bangor, Gwynedd LL57 2UW, UK. [email protected].
  6. Cell Cycle and Genome Stability Group, Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark. [email protected].
  7. Structural Biology and NMR Laboratory, Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark. [email protected].
  8. Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK. [email protected].
  9. North West Cancer Research Institute, Bangor University, Bangor, Gwynedd LL57 2UW, UK. [email protected].
  10. Cell Cycle and Genome Stability Group, Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark. [email protected].
  11. Cell Cycle and Genome Stability Group, Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark. [email protected].

PMID: 28441348 PMCID: PMC5448002 DOI: 10.3390/genes8050128

Abstract

In fission yeast, the small, intrinsically disordered protein S-phase delaying protein 1 (Spd1) blocks DNA replication and causes checkpoint activation at least in part, by inhibiting the enzyme ribonucleotide reductase, which is responsible for the synthesis of DNA. The CRL4

Keywords: CRL4Cdt2; DNA replication; PCNA; checkpoints; deoxynucleotide salvage; fission yeast; intrinsically disordered proteins; ribonucleotide reductase

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