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Malays J Med Sci. 2017 Mar;24(1):113-116. doi: 10.21315/mjms2017.24.1.12. Epub 2017 Feb 24.

Paraneoplastic Neurological Disorder in Nasopharyngeal Carcinoma.

The Malaysian journal of medical sciences : MJMS

Sze Yin Ng, Min Han Kongg, Mohd Razif Mohamad Yunus

Affiliations

  1. Department of Otorhinolaryngology, Head & Neck Surgery, UKM Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia.

PMID: 28381934 PMCID: PMC5346009 DOI: 10.21315/mjms2017.24.1.12

Abstract

Paraneoplastic neurological disorder (PND) is a condition due to immune cross-reactivity between the tumour cells and the normal tissue, whereby the "onconeural" antibodies attack the normal host nervous system. It can present within weeks to months before or after the diagnosis of malignancies. Nasopharyngeal carcinoma is associated with paraneoplastic syndrome, for example, dermatomyositis, and rarely with a neurological disorder. We report on a case of nasopharyngeal carcinoma with probable PND. Otolaryngologists, oncologists and neurologists need to be aware of this condition in order to make an accurate diagnosis and to provide prompt treatment.

Keywords: PND; nasopharyngeal carcinoma; nervous system; neurological disorder; paraneoplastic polyneuropathy; paraneoplastic syndrome

Conflict of interest statement

Conflict of Interest There are no potential conflicts of interest, including specific financial interests and relationships and affiliations (other than those affiliations listed in the title page of

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