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Cancer Biol Med. 2017 Feb;14(1):60-65. doi: 10.20892/j.issn.2095-3941.2016.0089.

Association of genotypes of rs671 within.

Cancer biology & medicine

Lian-Qun Zhang, Xin Song, Xue-Ke Zhao, Jia Huang, Peng Zhang, Lu-Wen Wang, Hui Meng, Jian-Wei Ku, Guo-Qiang Kong, Tao Jiang, Xin-Min Li, Xiao-Long Lv, Teng Ma, Guo Yuan, Min-Jie Wu, Shou-Jia Hu, Shuang Lv, Tang-Juan Zhang, Ling-Fen Ji, Zong-Min Fan, Neng-Chao Wang, Yao-Wen Zhang, Fu-You Zhou, Li-Dong Wang

Affiliations

  1. Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
  2. Anyang Tumor Hospital, Anyang 455000, China.
  3. Cancer Research Center, Xinxiang Medical University, Xinxiang 453003, China.

PMID: 28443204 PMCID: PMC5365177 DOI: 10.20892/j.issn.2095-3941.2016.0089

Abstract

OBJECTIVE: : This study aimed to determine if gastric cardia adenocarcinoma (GCA) risk was associated with the lys (A or *2) allele at the rs671 (glu504lys) polymorphism within the aldehyde dehydrogenase 2 (

METHODS: : We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and low-incidence areas for both GCA and ESCC in China. TaqMan allele discrimination assay was used to genotype the rs671 polymorphism.

RESULTS: : Compared with

CONCLUSIONS: : Genotypes of rs671 at

Keywords: ALDH2; Gastric cardia adenocarcinoma; high- and low-incidence areas; rs671

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