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Zhang YL, Wang RC, Cheng K, et al. Roles of Rap1 signaling in tumor cell migration and invasion. Cancer Biol Med. 2017;14(1):90-99doi: 10.20892/j.issn.2095-3941.2016.0086.
Zhang, Y. L., Wang, R. C., Cheng, K., Ring, B. Z., & Su, L. (2017). Roles of Rap1 signaling in tumor cell migration and invasion. Cancer biology & medicine, 14(1), 90-99. https://doi.org/10.20892/j.issn.2095-3941.2016.0086
Zhang, Yi-Lei, et al. "Roles of Rap1 signaling in tumor cell migration and invasion." Cancer biology & medicine vol. 14,1 (2017): 90-99. doi: https://doi.org/10.20892/j.issn.2095-3941.2016.0086
Zhang YL, Wang RC, Cheng K, Ring BZ, Su L. Roles of Rap1 signaling in tumor cell migration and invasion. Cancer Biol Med. 2017 Feb;14(1):90-99. doi: 10.20892/j.issn.2095-3941.2016.0086. PMID: 28443208; PMCID: PMC5365179.
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Cancer Biol Med. 2017 Feb;14(1):90-99. doi: 10.20892/j.issn.2095-3941.2016.0086.

Roles of Rap1 signaling in tumor cell migration and invasion.

Cancer biology & medicine

Yi-Lei Zhang, Ruo-Chen Wang, Ken Cheng, Brian Z Ring, Li Su

Affiliations

  1. Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
  2. Sun Yat-sen University, Guangzhou 510275, China.
  3. Research Institute of Huazhong University of Science and Technology in Shenzhen, Shenzhen 518063, China.

PMID: 28443208 PMCID: PMC5365179 DOI: 10.20892/j.issn.2095-3941.2016.0086

Abstract

Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Through its interaction with other proteins, Rap1 plays many roles during cell invasion and metastasis in different cancers. The basic function of Rap1 is straightforward; it acts as a switch during cellular signaling transduction and regulated by its binding to either guanosine triphosphate (GTP) or guanosine diphosphate (GDP). However, its remarkably diverse function is rendered by its interplay with a large number of distinct Rap guanine nucleotide exchange factors and Rap GTPase activating proteins. This review summarizes the mechanisms by which Rap1 signaling can regulate cell invasion and metastasis, focusing on its roles in integrin and cadherin regulation, Rho GTPase control, and matrix metalloproteinase expression.

Keywords: Rap1; RapGAPs; RapGEFs; Tumor; metastasis

References

  1. Eur J Cell Biol. 2006 Apr;85(3-4):283-93 - PubMed
  2. Cancer Lett. 2015 Apr 10;359(2):241-9 - PubMed
  3. Oncogene. 2010 Jan 28;29(4):608-15 - PubMed
  4. Nat Rev Drug Discov. 2009 Dec;8(12):935-48 - PubMed
  5. Dev Cell. 2013 Dec 9;27(5):574-85 - PubMed
  6. J Cell Sci. 2003 Feb 1;116(Pt 3):435-40 - PubMed
  7. Cancer Lett. 2012 Jul 1;320(1):65-71 - PubMed
  8. Endocr Relat Cancer. 2012 Jul 22;19(4):575-88 - PubMed
  9. J Cell Sci. 2007 Jan 1;120(Pt 1):17-22 - PubMed
  10. J Biol Chem. 2011 Sep 30;286(39):33954-62 - PubMed
  11. Cell. 1989 Jan 13;56(1):77-84 - PubMed
  12. Trends Pharmacol Sci. 2013 May;34(5):283-9 - PubMed
  13. J Biochem. 2003 Oct;134(4):479-84 - PubMed
  14. Cancer Res. 2010 Feb 15;70(4):1389-97 - PubMed
  15. J Biol Chem. 2003 Oct 24;278(43):41756-67 - PubMed
  16. Clin Cancer Res. 2010 Jan 1;16(1):65-76 - PubMed
  17. Nat Rev Mol Cell Biol. 2001 May;2(5):369-77 - PubMed
  18. Oncogene. 2003 Jul 3;22(27):4243-56 - PubMed
  19. Biochim Biophys Acta. 2009 Apr;1788(4):790-6 - PubMed
  20. Cancer Res. 2008 May 15;68(10):3959-69 - PubMed
  21. Cell. 2011 Oct 14;147(2):275-92 - PubMed
  22. Cancer Res. 2006 Jan 15;66(2):898-906 - PubMed
  23. Cancer Res. 2009 Jun 15;69(12):4962-8 - PubMed
  24. Dev Cell. 2004 Oct;7(4):585-95 - PubMed
  25. Cell Adh Migr. 2011 Jul-Aug;5(4):323-31 - PubMed
  26. J Biol Chem. 2003 Apr 25;278(17 ):15232-8 - PubMed
  27. Science. 2001 Nov 9;294(5545):1299-304 - PubMed
  28. J Biol Chem. 1999 Dec 17;274(51):36663-9 - PubMed
  29. Nat Immunol. 2004 Oct;5(10):1045-51 - PubMed
  30. PLoS One. 2013;8(2):e56174 - PubMed
  31. Mol Cell Biol. 1999 Jan;19(1):733-44 - PubMed
  32. J Leukoc Biol. 2011 Apr;89(4):577-86 - PubMed
  33. J Cell Sci. 2005 Oct 15;118(Pt 20):4765-83 - PubMed
  34. Mol Pharmacol. 2013 Jan;83(1):122-8 - PubMed
  35. Mol Biol Cell. 2009 Apr;20(7):1916-25 - PubMed
  36. Cancer Res. 2009 Jan 15;69(2):449-57 - PubMed
  37. Cell. 2010 Apr 2;141(1):52-67 - PubMed
  38. Nat Immunol. 2004 Apr;5(4):363-72 - PubMed
  39. J Biol Chem. 2013 Sep 27;288(39):27712-23 - PubMed
  40. EMBO J. 1993 Sep;12 (9):3475-85 - PubMed
  41. Mol Biol Cell. 2012 Dec;23(24):4751-65 - PubMed
  42. Cell. 2011 Nov 23;147(5):992-1009 - PubMed
  43. Trends Cell Biol. 2011 Oct;21(10):615-23 - PubMed
  44. Oncotarget. 2012 Apr;3(4):399-413 - PubMed
  45. Oncogene. 2012 May 31;31(22):2783-93 - PubMed
  46. J Biol Chem. 2005 Jun 24;280(25):24095-103 - PubMed
  47. Nature. 1998 Jul 23;394(6691):337-43 - PubMed
  48. Oncogene. 2015 Mar 12;34(11):1451-62 - PubMed
  49. J Biol Chem. 2000 Feb 4;275(5):3722-8 - PubMed
  50. J Cell Biol. 2004 Oct 11;167(1):111-22 - PubMed
  51. Cancer Sci. 2011 Apr;102(4):828-36 - PubMed
  52. Breast Cancer Res. 2011 Mar 23;13(2):R31 - PubMed
  53. J Cell Biol. 2007 Mar 12;176(6):863-75 - PubMed
  54. Cancer Res. 2006 Aug 15;66(16):7880-8 - PubMed
  55. Biochem J. 2014 Oct 15;463(2):257-70 - PubMed
  56. J Biol Chem. 2009 Apr 24;284(17):10995-9 - PubMed
  57. Mol Cell Biol. 2009 May;29(10):2521-31 - PubMed
  58. J Biol Chem. 2004 Oct 22;279(43):44490-6 - PubMed
  59. Sci Signal. 2013 May 28;6(277):ra39 - PubMed
  60. Biochem Soc Trans. 2003 Feb;31(Pt 1):83-6 - PubMed
  61. Curr Biol. 2010 Sep 14;20(17):R754-63 - PubMed
  62. Carcinogenesis. 2012 Nov;33(11):2147-54 - PubMed
  63. Curr Biol. 2006 Sep 19;16(18):1796-806 - PubMed
  64. Nature. 2010 Apr 15;464(7291):1062-6 - PubMed
  65. EMBO J. 2001 Jul 2;20(13):3333-41 - PubMed
  66. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11427-32 - PubMed
  67. Mol Biol Cell. 2009 Dec;20(24):5156-65 - PubMed
  68. Cancer Genomics Proteomics. 2012 Sep-Oct;9(5):321-7 - PubMed
  69. Mol Cell Biol. 2007 Oct;27(19):6647-58 - PubMed
  70. Oncogene. 2003 Sep 18;22(40):6243-56 - PubMed
  71. J Biol Chem. 2013 Aug 23;288(34):24636-46 - PubMed
  72. J Biol Chem. 2011 May 27;286(21):18492-504 - PubMed
  73. EMBO J. 1998 Oct 15;17(20):5905-12 - PubMed
  74. Nature. 2001 Apr 19;410(6831):944-8 - PubMed
  75. Cell. 1997 Apr 4;89(1):73-82 - PubMed
  76. Cell. 2003 Mar 7;112(5):673-84 - PubMed
  77. J Cell Sci. 2014 Jun 15;127(Pt 12):2647-58 - PubMed
  78. Cell Signal. 2008 Jun;20(6):1104-16 - PubMed
  79. Oncol Rep. 2012 Aug;28(2):622-8 - PubMed
  80. Genes Cells. 2008 Jun;13(6):549-69 - PubMed

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