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Wang B, Ge Z, Cheng Z, et al. Tanshinone IIA suppresses the progression of atherosclerosis by inhibiting the apoptosis of vascular smooth muscle cells and the proliferation and migration of macrophages induced by ox-LDL. Biol Open. 2017;6(4):489-495doi: 10.1242/bio.024133.
Wang, B., Ge, Z., Cheng, Z., & Zhao, Z. (2017). Tanshinone IIA suppresses the progression of atherosclerosis by inhibiting the apoptosis of vascular smooth muscle cells and the proliferation and migration of macrophages induced by ox-LDL. Biology open, 6(4), 489-495. https://doi.org/10.1242/bio.024133
Wang, Baocai, et al. "Tanshinone IIA suppresses the progression of atherosclerosis by inhibiting the apoptosis of vascular smooth muscle cells and the proliferation and migration of macrophages induced by ox-LDL." Biology open vol. 6,4 (2017): 489-495. doi: https://doi.org/10.1242/bio.024133
Wang B, Ge Z, Cheng Z, Zhao Z. Tanshinone IIA suppresses the progression of atherosclerosis by inhibiting the apoptosis of vascular smooth muscle cells and the proliferation and migration of macrophages induced by ox-LDL. Biol Open. 2017 Apr 15;6(4):489-495. doi: 10.1242/bio.024133. PMID: 28412716; PMCID: PMC5399561.
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Biol Open. 2017 Apr 15;6(4):489-495. doi: 10.1242/bio.024133.

Tanshinone IIA suppresses the progression of atherosclerosis by inhibiting the apoptosis of vascular smooth muscle cells and the proliferation and migration of macrophages induced by ox-LDL.

Biology open

Baocai Wang, Zhenwei Ge, Zhaoyun Cheng, Ziniu Zhao

Affiliations

  1. Department of Cardiovascular Surgery, Henan Provincial People's Hospital, Zhengzhou 450003, People's Republic of China.
  2. Department of Cardiovascular Surgery, Henan Provincial People's Hospital, Zhengzhou 450003, People's Republic of China [email protected].

PMID: 28412716 PMCID: PMC5399561 DOI: 10.1242/bio.024133

Abstract

The profound inhibitory effect of Tanshinone IIA (Tan IIA) on atherosclerosis has been demonstrated, whereas the latent mechanism is not completely cleared. This study aimed to investigate the cellular and molecular mechanisms underlying Tan IIA protecting against atherosclerosis. Oil Red O staining and ELISA assay showed that Tan IIA suppressed the progress of atherosclerosis and reduced the levels of inflammatory cytokines in serum of apolipoprotein E deficient (ApoE

© 2017. Published by The Company of Biologists Ltd.

Keywords: Atherosclerosis; Macrophages; Tanshinone IIA; Vascular smooth muscle cells; ox-LDL

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