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Kimura K, Sipponen P, Unge P, et al. Comparison of Gastric Histology Among Swedish and Japanese Patients with Peptic Ulcer and <emph type="2">Helicobacter pylori</emph> Infection. Scand J Gastroenterol. 2003;38(5):491-497doi: 10.1080/00365520310000366.
Kimura, K., Sipponen, P., Unge, P., Ekström, P., Satoh, K., Hellblom, M., Ohlin, B., Stubberöd, A., Kihira, K., Yube, T., & Yoshida, Y. (2003). Comparison of Gastric Histology Among Swedish and Japanese Patients with Peptic Ulcer and <emph type="2">Helicobacter pylori</emph> Infection. Scandinavian journal of gastroenterology, 38(5), 491-497. https://doi.org/10.1080/00365520310000366
Kimura, K, et al. "Comparison of Gastric Histology Among Swedish and Japanese Patients with Peptic Ulcer and <emph type="2">Helicobacter pylori</emph> Infection." Scandinavian journal of gastroenterology vol. 38,5 (2003): 491-497. doi: https://doi.org/10.1080/00365520310000366
Kimura K, Sipponen P, Unge P, Ekström P, Satoh K, Hellblom M, Ohlin B, Stubberöd A, Kihira K, Yube T, Yoshida Y. Comparison of Gastric Histology Among Swedish and Japanese Patients with Peptic Ulcer and <emph type="2">Helicobacter pylori</emph> Infection. Scand J Gastroenterol. 2003;38(5):491-497. doi: 10.1080/00365520310000366. PMID: 28443767.
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Scand J Gastroenterol. 2003;38(5):491-497. doi: 10.1080/00365520310000366.

Comparison of Gastric Histology Among Swedish and Japanese Patients with Peptic Ulcer and <emph type="2">Helicobacter pylori</emph> Infection.

Scandinavian journal of gastroenterology

K Kimura, P Sipponen, P Unge, P Ekström, K Satoh, M Hellblom, B Ohlin, A Stubberöd, K Kihira, T Yube, Y Yoshida

Affiliations

  1. a Dept. of Gastroenterology Jichi Medical School Yakushiji, Tochigi-ken Japan.
  2. b Dept. of Pathology HUCH Jorvi Hospital Espoo Finland.
  3. c Dept. of Medicine Bollnäs Hospital Sweden.
  4. d Dept. of Surgery Gävle-Sandvikens Hospital Sweden.
  5. e Dept. of Medicine Lasarettet, Östersund Sweden.
  6. f Blekinge Hospital Karlskrona Sweden.
  7. g Värnamo Hospital Värnamo Sweden.
  8. h Dept. of Internal Medicine Nasu Minami Hospital Tochigi Japan.
  9. i Dept. of Internal Medicine Omiya Medical Center of Jichi Medical School Saitama-ken Japan.

PMID: 28443767 DOI: 10.1080/00365520310000366

Abstract

BACKGROUND: The natural course of Helicobacter pylori gastritis may vary between different ethnic groups. Gastric histopathology and the occurrence of H. pylori organisms in the stomach were investigated in healed duodenal (DU) and gastric (GU) ulcer patients recruited in Sweden (S) and Japan (J) in an identical trial.

METHODS: In 203 patients (JGU = 39, JDU = 55, SDU = 109), various morphological gastritis variables and H. pylori were assessed from biopsy specimens obtained using a specific sampling protocol and interpreted according to guidelines of the updated Sydney grading system.

RESULTS: The ratio of GU:DU was observed to be very different between the recruited Japanese (39:55) and Swedish (0:109) patients. A comparison of data from SDU and JDU showed that the prevalence of H. pylori infection and the antral predominant gastritis demonstrated by both SDU and JDU were essentially identical. A comparison of data from JDU and JGU demonstrated a greater prevalence of H. pylori infection in the antrum, but not corpus, of JDU compared to JGU patients. The prevalence of atrophy and intestinal metaplasia was higher in both the antrum and corpus of JGU compared to JDU in all patients.

CONCLUSIONS: The site specified biopsy methodology and standardized interpretation criteria utilized in this study clearly show that the histotopographic profile of Swedish and Japanese DU patients is essentially the same.

Keywords: Duodenal/gastric Ulcer; Ethnicity; Helicobacter Pylori Infection; Histotopographic Profile

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