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Miller LE, Sloniewsky MJ, Gibbons TE, et al. Long-term clinical benefit and cost-effectiveness of an 8-week multimodal knee osteoarthritis management program incorporating intra-articular sodium hyaluronate (Hyalgan. J Pain Res. 2017;10:1045-1054doi: 10.2147/JPR.S132497.
Miller, L. E., Sloniewsky, M. J., Gibbons, T. E., Johnston, J. G., Vosler, K. D., & Nasir, S. (2017). Long-term clinical benefit and cost-effectiveness of an 8-week multimodal knee osteoarthritis management program incorporating intra-articular sodium hyaluronate (Hyalgan. Journal of pain research, 101045-1054. https://doi.org/10.2147/JPR.S132497
Miller, Larry E, et al. "Long-term clinical benefit and cost-effectiveness of an 8-week multimodal knee osteoarthritis management program incorporating intra-articular sodium hyaluronate (Hyalgan." Journal of pain research vol. 10 (2017): 1045-1054. doi: https://doi.org/10.2147/JPR.S132497
Miller LE, Sloniewsky MJ, Gibbons TE, Johnston JG, Vosler KD, Nasir S. Long-term clinical benefit and cost-effectiveness of an 8-week multimodal knee osteoarthritis management program incorporating intra-articular sodium hyaluronate (Hyalgan. J Pain Res. 2017 May 05;10:1045-1054. doi: 10.2147/JPR.S132497. eCollection 2017. PMID: 28503072; PMCID: PMC5426467.
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J Pain Res. 2017 May 05;10:1045-1054. doi: 10.2147/JPR.S132497. eCollection 2017.

Long-term clinical benefit and cost-effectiveness of an 8-week multimodal knee osteoarthritis management program incorporating intra-articular sodium hyaluronate (Hyalgan.

Journal of pain research

Larry E Miller, Michael J Sloniewsky, Thomas E Gibbons, Janice G Johnston, Kent D Vosler, Saad Nasir

Affiliations

  1. Miller Scientific Consulting, Inc., Asheville, NC.
  2. RMG Holding, Inc., Florence.
  3. Doctors Care, PA, Columbia, SC.
  4. Arrowhead Health Centers, Glendale, AZ.
  5. Fidia Pharma USA Inc., Parsippany, NJ, USA.

PMID: 28503072 PMCID: PMC5426467 DOI: 10.2147/JPR.S132497

Abstract

BACKGROUND: Given the poor long-term effectiveness of focused nonsurgical knee osteoarthritis (OA) treatments, alternative therapies are needed for patients who have unsuccessfully exhausted nonsurgical options.

METHODS: A telephone interview was conducted in patients who participated in a single 8-week multimodal knee OA treatment program (mean follow-up: 3.7 years, range: 2.7-4.9 years). The program consisted of five intra-articular knee injections of sodium hyaluronate (Hyalgan

RESULTS: A total of 218 patients (54%) provided long-term follow-up data. Knee pain severity decreased 60% and WOMAC subscores decreased 33%-42% compared to baseline (all

CONCLUSION: Participation in a single 8-week knee OA treatment program, which included one cycle of five intra-articular knee injections of sodium hyaluronate given at weekly intervals, is highly cost-effective and provides clinically meaningful reductions in patient symptoms that are maintained over 3.7 years mean follow-up.

Keywords: Hyalgan®; arthroplasty; economic model; hyaluronic acid; pragmatic; viscosupplementation

Conflict of interest statement

Disclosure SN is an employee of Fidia Pharma USA Inc. The authors report no conflicts of interest in this work.

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