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Front Physiol. 2017 Apr 20;8:230. doi: 10.3389/fphys.2017.00230. eCollection 2017.

LncRNA-Six1 Encodes a Micropeptide to Activate .

Frontiers in physiology

Bolin Cai, Zhenhui Li, Manting Ma, Zhijun Wang, Peigong Han, Bahareldin A Abdalla, Qinghua Nie, Xiquan Zhang

Affiliations

  1. Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural UniversityGuangzhou, China.
  2. Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of AgricultureGuangzhou, China.
  3. National-Local Joint Engineering Research Center for Livestock BreedingGuangzhou, China.

PMID: 28473774 PMCID: PMC5397475 DOI: 10.3389/fphys.2017.00230

Abstract

Long non-coding RNAs (lncRNAs) play important roles in epigenetic regulation of skeletal muscle development. In our previous RNA-seq study (accession number GSE58755), we found that lncRNA-Six1 is an lncRNA that is differentially expressed between White Recessive Rock (WRR) and Xinghua (XH) chicken. In this study, we have further demonstrated that lncRNA-Six1 is located 432 bp upstream of the gene encoding the protein Six homeobox 1 (

Keywords: Six1; cis-acting; lncRNA-Six1; micropeptide; muscle growth

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