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Bello-Roufai D, Soares DG, Kerrou K, et al. Long-term complete response in a breast cancer patient with skeletal muscle metastases diagnosed using 18F-FDG-PET. Oxf Med Case Reports. 2017;2017(2):omx002doi: 10.1093/omcr/omx002.
Bello-Roufai, D., Soares, D. G., Kerrou, K., Khalil, A., Richard, S., Gligorov, J., & Lotz, J. P. (2017). Long-term complete response in a breast cancer patient with skeletal muscle metastases diagnosed using 18F-FDG-PET. Oxford medical case reports, 2017(2), omx002. https://doi.org/10.1093/omcr/omx002
Bello-Roufai, Diana, et al. "Long-term complete response in a breast cancer patient with skeletal muscle metastases diagnosed using 18F-FDG-PET." Oxford medical case reports vol. 2017,2 (2017): omx002. doi: https://doi.org/10.1093/omcr/omx002
Bello-Roufai D, Soares DG, Kerrou K, Khalil A, Richard S, Gligorov J, Lotz JP. Long-term complete response in a breast cancer patient with skeletal muscle metastases diagnosed using 18F-FDG-PET. Oxf Med Case Reports. 2017 Feb 01;2017(2):omx002. doi: 10.1093/omcr/omx002. eCollection 2017 Feb. PMID: 28473915; PMCID: PMC5410881.
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Oxf Med Case Reports. 2017 Feb 01;2017(2):omx002. doi: 10.1093/omcr/omx002. eCollection 2017 Feb.

Long-term complete response in a breast cancer patient with skeletal muscle metastases diagnosed using 18F-FDG-PET.

Oxford medical case reports

Diana Bello-Roufai, Daniele G Soares, Khaldoun Kerrou, Ahmed Khalil, Sandrine Richard, Joseph Gligorov, Jean-Pierre Lotz

Affiliations

  1. Department of Medical Oncology, Hospital Tenon (Public Assistance - Paris Hospitals, AP-HP), 4 rue de la Chine 75020 Paris, France.
  2. Alliance Pour la Recherche En Cancérologie (APREC), Department of Medical Oncology, Hospital Tenon, 4 rue de la Chine 75020 Paris, France.
  3. Department of Nuclear Medicine, Hospital Tenon (Public Assistance - Paris Hospitals, AP-HP), 4 rue de la Chine 75020 Paris, France.
  4. Sorbonne Universities, University Pierre et Marie Curie (IUC-UPMC Univ Paris 06), 4 place Jussieu 75005 Paris, France.

PMID: 28473915 PMCID: PMC5410881 DOI: 10.1093/omcr/omx002

Abstract

Common sites for metastatic spreading from breast cancer are bones, lungs and liver, the skeletal muscle being an unusual site. Although rare, when skeletal muscle metastases occur they are associated with a poor prognosis. These metastases are clinically difficult to diagnose since they can be found without pain symptoms. Radiologically, magnetic resonance imaging has been considered better than computed tomography for imaging of the muscles and has been the first procedure to use in case of muscle metastasis suspicion. In the last years, positron emission tomography (PET) with 18Fluorine-2-fluoro-2-deoxy-d-glucose (18F-FDG) has emerged as the main imaging tool. We here report a case of a hormone receptor-positive/human epidermal growth factor receptor 2-negative patient who presented with a recurrent infiltrating ductal carcinoma and diffuse skeletal muscle metastases detected by 18F-FDG-PET. The treatment of the patient with exemestane and everolimus led to a durable complete response.

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