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Park J, Song H, Kim SK, et al. Effects of ginseng on two main sex steroid hormone receptors: estrogen and androgen receptors. J Ginseng Res. 2016;41(2):215-221doi: 10.1016/j.jgr.2016.08.005.
Park, J., Song, H., Kim, S. K., Lee, M. S., Rhee, D. K., & Lee, Y. (2017). Effects of ginseng on two main sex steroid hormone receptors: estrogen and androgen receptors. Journal of ginseng research, 41(2), 215-221. https://doi.org/10.1016/j.jgr.2016.08.005
Park, Joonwoo, et al. "Effects of ginseng on two main sex steroid hormone receptors: estrogen and androgen receptors." Journal of ginseng research vol. 41,2 (2017): 215-221. doi: https://doi.org/10.1016/j.jgr.2016.08.005
Park J, Song H, Kim SK, Lee MS, Rhee DK, Lee Y. Effects of ginseng on two main sex steroid hormone receptors: estrogen and androgen receptors. J Ginseng Res. 2017 Apr;41(2):215-221. doi: 10.1016/j.jgr.2016.08.005. Epub 2016 Aug 23. PMID: 28413327; PMCID: PMC5386121.
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J Ginseng Res. 2017 Apr;41(2):215-221. doi: 10.1016/j.jgr.2016.08.005. Epub 2016 Aug 23.

Effects of ginseng on two main sex steroid hormone receptors: estrogen and androgen receptors.

Journal of ginseng research

Joonwoo Park, Heewon Song, Si-Kwan Kim, Myeong Soo Lee, Dong-Kwon Rhee, YoungJoo Lee

Affiliations

  1. Department of Bioscience and Biotechnology, College of Life Science, Sejong University, Kwangjingu, Kunjadong, Seoul, Korea.
  2. Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju, Korea.
  3. Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea.
  4. School of Pharmacy, Sungkyunkwan University, Suwon, Korea.

PMID: 28413327 PMCID: PMC5386121 DOI: 10.1016/j.jgr.2016.08.005

Abstract

Ginseng has been used in China for at least two millennia and is now popular in over 35 countries. It is one of the world's popular herbs for complementary and alternative medicine and has been shown to have helpful effects on cognition and blood circulation, as well as anti-aging, anti-cancer, and anti-diabetic effects, among many others. The pharmacological activities of ginseng are dependent mainly on ginsenosides. Ginsenosides have a cholesterol-like four trans-ring steroid skeleton with a variety of sugar moieties. Nuclear receptors are one of the most important molecular targets of ginseng, and reports have shown that members of the nuclear receptor superfamily are regulated by a variety of ginsenosides. Here, we review the published literature on the effects of ginseng and its constituents on two main sex steroid hormone receptors: estrogen and androgen receptors. Furthermore, we discuss applications for sex steroid hormone receptor modulation and their therapeutic efficacy.

Keywords: androgen receptor; estrogen receptor; ginseng; nuclear receptor; steroid hormone receptor

References

  1. Pigment Cell Res. 2004 Aug;17(4):407-12 - PubMed
  2. J Med Invest. 2007 Aug;54(3-4):381-4 - PubMed
  3. Mol Endocrinol. 2003 Feb;17(2):203-8 - PubMed
  4. J Ginseng Res. 2013 Apr;37(2):176-86 - PubMed
  5. Br J Pharmacol. 2007 Sep;152(2):172-4 - PubMed
  6. Int J Androl. 2003 Feb;26(1):16-20 - PubMed
  7. J Neurochem. 2009 Jun;109 (5):1338-47 - PubMed
  8. J Ginseng Res. 2015 Oct;39(4):287-98 - PubMed
  9. J Microbiol. 2005 Oct;43(5):456-62 - PubMed
  10. Mol Cell Endocrinol. 2002 Dec 30;198(1-2):61-7 - PubMed
  11. J Clin Endocrinol Metab. 2004 Jul;89(7):3510-5 - PubMed
  12. Biochim Biophys Acta. 2012 Apr;1820(4):453-60 - PubMed
  13. Int J Clin Pharmacol Res. 1999;19(3):89-99 - PubMed
  14. J Clin Endocrinol Metab. 2002 Aug;87(8):3691-5 - PubMed
  15. Biochem Biophys Res Commun. 2015 Oct 16;466(2):232-9 - PubMed
  16. Climacteric. 2015 Apr;18(2):260-9 - PubMed
  17. Front Neuroendocrinol. 2010 Oct;31(4):400-19 - PubMed
  18. J Steroid Biochem Mol Biol. 2014 May;141:104-12 - PubMed
  19. J Ginseng Res. 2011 Nov;35(4):389-98 - PubMed
  20. Int J Mol Sci. 2014 May 06;15(5):7827-40 - PubMed
  21. J Ginseng Res. 2014 Apr;38(2):89-96 - PubMed
  22. Eur J Pharmacol. 2012 May 15;683(1-3):27-34 - PubMed
  23. Evid Based Complement Alternat Med. 2015;2015:913158 - PubMed
  24. Genes Nutr. 2008 Apr;3(1):7-13 - PubMed
  25. J Ginseng Res. 2012 Oct;36(4):354-68 - PubMed
  26. J Med Food. 2015 Mar;18(3):354-62 - PubMed
  27. Zhong Xi Yi Jie He Xue Bao. 2006 Mar;4(2):156-9 - PubMed
  28. J Ginseng Res. 2014 Jul;38(3):161-6 - PubMed
  29. Trends Mol Med. 2013 Mar;19(3):197-209 - PubMed
  30. J Tradit Chin Med. 2015 Aug;35(4):460-7 - PubMed
  31. Mol Endocrinol. 2000 Oct;14(10):1649-60 - PubMed
  32. Neuroscience. 2012 Sep 18;220:191-200 - PubMed
  33. J Ginseng Res. 2012 Jul;36(3):225-41 - PubMed
  34. Physiol Rev. 2007 Jul;87(3):905-31 - PubMed
  35. Breast Cancer Res Treat. 2008 Apr;108(3):351-61 - PubMed
  36. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5936-41 - PubMed
  37. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10966-71 - PubMed
  38. J Ginseng Res. 2013 Mar;37(1):30-6 - PubMed
  39. J Ginseng Res. 2013 Mar;37(1):1-7 - PubMed
  40. Arch Intern Med. 2001 May 14;161(9):1161-72 - PubMed
  41. J Ginseng Res. 2013 Oct;37(4):379-88 - PubMed
  42. Physiol Behav. 2010 Feb 9;99(2):151-62 - PubMed
  43. Br J Pharmacol. 2007 Sep;152(2):207-15 - PubMed
  44. Eur J Pharmacol. 2012 Jan 30;675(1-3):15-21 - PubMed
  45. Eur J Pharmacol. 2014 Oct 15;741:230-6 - PubMed
  46. J Ginseng Res. 2015 Jan;39(1):69-75 - PubMed
  47. J Ginseng Res. 2012 Apr;36(2):169-75 - PubMed
  48. Baillieres Clin Endocrinol Metab. 1998 Dec;12(4):543-57 - PubMed
  49. FEBS Lett. 2006 May 29;580(13):3211-6 - PubMed
  50. J Steroid Biochem Mol Biol. 2003 Jan;84(1):41-9 - PubMed
  51. J Ethnopharmacol. 2013 Jul 9;148(2):474-85 - PubMed
  52. Evid Based Complement Alternat Med. 2012;2012:693717 - PubMed
  53. Endocr Rev. 2013 Jun;34(3):309-38 - PubMed
  54. Eur J Pharm Sci. 2011 Sep 18;44(1-2):117-26 - PubMed
  55. Mol Endocrinol. 2002 Jan;16(1):70-84 - PubMed
  56. Toxicol Appl Pharmacol. 2010 Aug 1;246(3):171-83 - PubMed
  57. Clin Cancer Res. 2012 Jan 1;18(1):6-8 - PubMed
  58. Steroids. 1998 Jul-Aug;63(7-8):421-4 - PubMed
  59. Mol Nutr Food Res. 2013 Jan;57(1):100-13 - PubMed
  60. J Ginseng Res. 2013 Jul;37(3):315-23 - PubMed
  61. Neuropharmacology. 2012 Sep;63(3):349-61 - PubMed
  62. Arch Pathol Lab Med. 2011 Jan;135(1):63-6 - PubMed
  63. Mol Cell Endocrinol. 2014 May 25;389(1-2):71-83 - PubMed
  64. J Pharm Pharmacol. 2012 May;64(5):727-34 - PubMed
  65. Br J Pharmacol. 2003 Apr;138(7):1295-302 - PubMed
  66. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8739-43 - PubMed
  67. J Steroid Biochem Mol Biol. 2003 Mar;84(4):463-8 - PubMed
  68. J Clin Invest. 2010 Jul;120(7):2319-30 - PubMed
  69. Br J Clin Pharmacol. 2008 Oct;66(4):444-50 - PubMed
  70. Front Physiol. 2014 Mar 19;5:98 - PubMed
  71. Biochem Pharmacol. 1999 Dec 1;58(11):1685-93 - PubMed
  72. Biol Pharm Bull. 2006 Oct;29(10):2051-5 - PubMed
  73. Br J Pharmacol. 2009 Feb;156(4):626-37 - PubMed
  74. Br J Cancer. 2008 Feb 26;98 (4):792-802 - PubMed
  75. Am J Clin Nutr. 1998 Dec;68(6 Suppl):1333S-1346S - PubMed
  76. J Proteomics. 2012 Jun 27;75(12):3592-604 - PubMed
  77. Reproduction. 2003 Feb;125(2):143-9 - PubMed
  78. Menopause. 2012 Apr;19(4):461-6 - PubMed
  79. Biochem Pharmacol. 2014 Mar 1;88(1):66-74 - PubMed
  80. Genet Mol Res. 2010 Jan 26;9(1):128-33 - PubMed
  81. J Ginseng Res. 2013 Jul;37(3):261-8 - PubMed
  82. Drugs. 2004;64(6):633-48 - PubMed
  83. Arch Pharm Res. 2009 Apr;32(4):505-13 - PubMed
  84. J Sex Med. 2010 Apr;7(4 Pt 1):1469-77 - PubMed
  85. Int Orthop. 2013 Oct;37(10 ):2065-70 - PubMed
  86. Br J Pharmacol. 2006 Mar;147(5):542-51 - PubMed
  87. J Nat Med. 2012 Jul;66(3):476-85 - PubMed
  88. Br J Pharmacol. 2013 Apr;168(7):1758-70 - PubMed
  89. Cancer Causes Control. 2000 Apr;11(4):289-98 - PubMed
  90. J Ginseng Res. 2011 Sep;35(3):272-82 - PubMed
  91. Exp Biol Med (Maywood). 2009 Aug;234(8):880-907 - PubMed
  92. Mol Pharmacol. 2006 Dec;70(6):1916-24 - PubMed
  93. Mol Endocrinol. 2002 Oct;16(10):2181-7 - PubMed
  94. Steroids. 2014 Nov;90:13-29 - PubMed
  95. Steroids. 2000 May;65(5):227-51 - PubMed
  96. Pharmacol Rev. 2006 Dec;58(4):773-81 - PubMed
  97. J Ginseng Res. 2016 Apr;40(2):185-95 - PubMed
  98. J Neuroendocrinol. 2012 Jan;24(1):160-73 - PubMed
  99. Acta Pharmacol Sin. 2008 Oct;29(10 ):1209-14 - PubMed

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