J Bioanal Biomed. 2015 Dec;7(6). doi: 10.4172/1948-593X.1000e133. Epub 2015 Dec 11.

The Biochemical Cascades of the Human Pancreatic .

Journal of bioanalysis & biomedicine

Joseph W Kim, John Z Luo, Luguang Luo

PMID: 28503255 PMCID: PMC5426857 DOI: 10.4172/1948-593X.1000e133

Abstract

Diabetes mellitus is a disease that poses a burden to the health care system due to its prevalence and chronic nature. Understanding β cell pathophysiology may lead to future therapeutic options for diabetes mellitus type 1 and 2. MicroRNAs (MiR) fine-tune β cell biochemical cascades through specific protein targets. This review argues that miRs may play a critical role in human islet β cell biology and are potential candidates for a new pharmacological strategy. We have reviewed and presented how miRs fine tune four biochemical cascades in islet β cells: glucose stimulated insulin secretion, β cell replication, apoptosis, and development. Only studies that examine human pancreatic islets either

Keywords: Diabetes; Human islet; Metabolism; miRNAs (miR); β cells

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Publication Types

• Journal Article

Grant support

• P20 RR018757/RR/NCRR NIH HHS/United States
• R01 DK097380/DK/NIDDK NIH HHS/United States