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Ishigami H, Matsumura T, Kasamatsu S, et al. Endoscopy-Guided Evaluation of Duodenal Mucosal Permeability in Functional Dyspepsia. Clin Transl Gastroenterol. 2017;8(4):e83doi: 10.1038/ctg.2017.12.
Ishigami, H., Matsumura, T., Kasamatsu, S., Hamanaka, S., Taida, T., Okimoto, K., Saito, K., Minemura, S., Maruoka, D., Nakagawa, T., Katsuno, T., Fujie, M., & Arai, M. (2017). Endoscopy-Guided Evaluation of Duodenal Mucosal Permeability in Functional Dyspepsia. Clinical and translational gastroenterology, 8(4), e83. https://doi.org/10.1038/ctg.2017.12
Ishigami, Hideaki, et al. "Endoscopy-Guided Evaluation of Duodenal Mucosal Permeability in Functional Dyspepsia." Clinical and translational gastroenterology vol. 8,4 (2017): e83. doi: https://doi.org/10.1038/ctg.2017.12
Ishigami H, Matsumura T, Kasamatsu S, Hamanaka S, Taida T, Okimoto K, Saito K, Minemura S, Maruoka D, Nakagawa T, Katsuno T, Fujie M, Arai M. Endoscopy-Guided Evaluation of Duodenal Mucosal Permeability in Functional Dyspepsia. Clin Transl Gastroenterol. 2017 Apr 06;8(4):e83. doi: 10.1038/ctg.2017.12. PMID: 28383567; PMCID: PMC5415894.
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Clin Transl Gastroenterol. 2017 Apr 06;8(4):e83. doi: 10.1038/ctg.2017.12.

Endoscopy-Guided Evaluation of Duodenal Mucosal Permeability in Functional Dyspepsia.

Clinical and translational gastroenterology

Hideaki Ishigami, Tomoaki Matsumura, Shingo Kasamatsu, Shinsaku Hamanaka, Takashi Taida, Kenichiro Okimoto, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Tomoo Nakagawa, Tatsuro Katsuno, Mai Fujie, Makoto Arai

Affiliations

  1. Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba-City, Japan.
  2. Clinical Engineering Center, Chiba University Hospital, Chiba-City, Japan.

PMID: 28383567 PMCID: PMC5415894 DOI: 10.1038/ctg.2017.12

Abstract

OBJECTIVES: The pathophysiology of functional dyspepsia (FD) is not fully understood. Impaired duodenal mucosal integrity characterized by increased mucosal permeability and/or low-grade inflammation was reported as potentially important etiologies. We aimed to determine the utility of a recently developed simple catheterization method to measure mucosal admittance (MA), the inverse of mucosal impedance, for evaluation of duodenal mucosal permeability in patients with FD.

METHODS: We conducted two prospective studies. In the first study, duodenal MA of 23 subjects was determined by catheterization during upper endoscopy, and transepithelial electrical resistance (TEER) of duodenal biopsy samples in Ussing chambers was measured to assess the correlation between MA and TEER. In the second study, duodenal MA of 21 patients with FD fulfilling the Rome III criteria was compared with that of 23 healthy subjects.

RESULTS: The mean MA and TEER values were 367.5±134.7 and 24.5±3.7 Ω cm

CONCLUSIONS: We demonstrated the presence of increased duodenal mucosal permeability in patients with FD by MA measurement using a simple catheterization method during upper endoscopy.

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