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Johansson JU, Woodling NS, Shi J, et al. Inflammatory Cyclooxygenase Activity and PGE. Curr Immunol Rev. 2015;11(2):125-131doi: 10.2174/1573395511666150707181414.
Johansson, J. U., Woodling, N. S., Shi, J., & Andreasson, K. I. (2015). Inflammatory Cyclooxygenase Activity and PGE. Current immunology reviews, 11(2), 125-131. https://doi.org/10.2174/1573395511666150707181414
Johansson, Jenny U, et al. "Inflammatory Cyclooxygenase Activity and PGE." Current immunology reviews vol. 11,2 (2015): 125-131. doi: https://doi.org/10.2174/1573395511666150707181414
Johansson JU, Woodling NS, Shi J, Andreasson KI. Inflammatory Cyclooxygenase Activity and PGE. Curr Immunol Rev. 2015 Aug;11(2):125-131. doi: 10.2174/1573395511666150707181414. PMID: 28413375; PMCID: PMC5384338.
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Curr Immunol Rev. 2015 Aug;11(2):125-131. doi: 10.2174/1573395511666150707181414.

Inflammatory Cyclooxygenase Activity and PGE.

Current immunology reviews

Jenny U Johansson, Nathaniel S Woodling, Ju Shi, Katrin I Andreasson

Affiliations

  1. Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
  2. Present address: SRI International, Menlo Park, CA, USA.
  3. Present address: Institute of Healthy Ageing, University College London, London, UK.
  4. Present address: True North Therapeutics, South San Francisco, CA, USA.

PMID: 28413375 PMCID: PMC5384338 DOI: 10.2174/1573395511666150707181414

Abstract

The inflammatory response is a fundamental driving force in the pathogenesis of Alzheimer's disease (AD). In the setting of accumulating immunogenic Aß peptide assemblies, microglia, the innate immune cells of the brain, generate a non-resolving immune response and fail to adequately clear accumulating Aß peptides, accelerating neuronal and synaptic injury. Pathological, biomarker, and imaging studies point to a prominent role of the innate immune response in AD development, and the molecular components of this response are beginning to be unraveled. The inflammatory cyclooxygenase-PGE

Keywords: Alzheimer’s disease; EP2 receptor; EP3 receptor; EP4 receptor; amyloid beta; cyclooxgenases; inflammation; microglia; prostaglandin E2

References

  1. Nat Genet. 2011 May;43(5):436-41 - PubMed
  2. J Immunol. 2009 Aug 15;183(4):2642-9 - PubMed
  3. J Neurosci. 2000 Aug 1;20(15):5709-14 - PubMed
  4. Cell Physiol Biochem. 2007;20(6):947-56 - PubMed
  5. Neurobiol Dis. 2002 Aug;10 (3):279-88 - PubMed
  6. J Neurosci. 2012 Jul 25;32(30):10117-28 - PubMed
  7. Neurology. 2007 May 22;68(21):1800-8 - PubMed
  8. J Exp Med. 2009 Jan 16;206(1):61-8 - PubMed
  9. J Immunol. 2008 Jun 15;180(12):8222-30 - PubMed
  10. Arch Neurol. 2008 Jul;65(7):896-905 - PubMed
  11. Arch Neurol. 2003 Aug;60(8):1119-22 - PubMed
  12. Am J Pathol. 2009 Jun;174(6):2300-9 - PubMed
  13. J Neurosci. 2012 Nov 28;32(48):17321-31 - PubMed
  14. Brain Res. 2010 Apr 6;1323:11-7 - PubMed
  15. J Biol Chem. 2008 Apr 11;283(15):9692-703 - PubMed
  16. Ann Neurol. 2012 Nov;72 (5):788-98 - PubMed
  17. Science. 2011 Sep 9;333(6048):1456-8 - PubMed
  18. J Neurosci. 2008 Aug 13;28(33):8354-60 - PubMed
  19. Sci Transl Med. 2014 Jul 2;6(243):243ra86 - PubMed
  20. Ann Neurol. 2008 Sep;64(3):304-14 - PubMed
  21. J Cardiovasc Pharmacol. 2007 Nov;50(5):470-9 - PubMed
  22. Neuron. 2010 Jun 10;66(5):631-45 - PubMed
  23. N Engl J Med. 2013 Jan 10;368(2):107-16 - PubMed
  24. Am J Pathol. 2010 Feb;176(2):850-60 - PubMed
  25. N Engl J Med. 2013 Jan 10;368(2):117-27 - PubMed
  26. Proc Natl Acad Sci U S A. 2001 Jan 16;98 (2):507-12 - PubMed
  27. Mol Cell. 2001 Jan;7(1):161-71 - PubMed
  28. Am J Hum Genet. 2008 Nov;83(5):623-32 - PubMed
  29. Science. 2013 May 24;340(6135):924-c - PubMed
  30. Nat Med. 2006 Feb;12(2):225-9 - PubMed
  31. J Immunol. 2010 Jun 15;184(12):7207-18 - PubMed
  32. Nat Immunol. 2012 Nov;13(11):1118-28 - PubMed
  33. Brain Behav Immun. 2010 Feb;24(2):243-53 - PubMed
  34. Science. 2012 Mar 23;335(6075):1503-6 - PubMed
  35. J Clin Invest. 2015 Jan;125(1):350-64 - PubMed
  36. Nat Neurosci. 2007 Sep;10(9):1131-3 - PubMed
  37. Nat Neurosci. 2013 Dec;16(12):1896-905 - PubMed
  38. J Biol Chem. 2011 Feb 25;286(8):6393-401 - PubMed
  39. Neurobiol Aging. 2012 Sep;33(9):2215-9 - PubMed
  40. Neurology. 1997 Mar;48(3):626-32 - PubMed
  41. J Neurosci. 2014 Apr 23;34(17):5882-94 - PubMed
  42. Eur J Neurosci. 2006 Sep;24(5):1245-51 - PubMed
  43. Nat Neurosci. 2014 Mar;17(3):400-6 - PubMed
  44. J Neurosci. 2007 May 16;27(20):5394-404 - PubMed
  45. Neurology. 1999 Oct 22;53(7):1495-8 - PubMed
  46. Curr Top Microbiol Immunol. 2009;336:137-53 - PubMed
  47. Dement Geriatr Cogn Disord. 2007;23(1):8-21 - PubMed
  48. Neurobiol Aging. 2000 May-Jun;21(3):383-421 - PubMed
  49. J Immunol. 2004 Jul 1;173(1):559-65 - PubMed
  50. Neuron. 2012 May 24;74(4):691-705 - PubMed
  51. Science. 2004 Dec 10;306(5703):1954-7 - PubMed
  52. Neurobiol Aging. 2001 Nov-Dec;22(6):983-91 - PubMed
  53. Nat Genet. 2011 May;43(5):429-35 - PubMed
  54. Science. 2010 Nov 5;330(6005):841-5 - PubMed
  55. Nat Genet. 2009 Oct;41(10):1094-9 - PubMed
  56. J Neurosci. 2013 Oct 2;33(40):16016-32 - PubMed
  57. Circ Res. 2006 Mar 3;98(4):499-504 - PubMed
  58. JAMA. 2003 Jun 4;289(21):2819-26 - PubMed
  59. Neuropsychopharmacology. 2005 Jun;30(6):1204-15 - PubMed
  60. J Neurosci. 2005 Nov 2;25(44):10180-7 - PubMed
  61. Prostaglandins Other Lipid Mediat. 2010 Apr;91(3-4):104-12 - PubMed
  62. J Neuroimmunol. 2007 Mar;184(1-2):69-91 - PubMed
  63. Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006338 - PubMed
  64. Cell. 2007 Dec 14;131(6):1164-78 - PubMed
  65. Nature. 2010 Nov 11;468(7321):253-62 - PubMed
  66. Nat Genet. 2013 Dec;45(12):1452-8 - PubMed
  67. Neurology. 2008 May 6;70(19):1672-7 - PubMed
  68. J Immunol. 2006 Oct 15;177(8):5499-508 - PubMed
  69. Neurochem Int. 2004 Oct;45(5):653-60 - PubMed
  70. Am J Pathol. 2010 Jul;177(1):346-54 - PubMed
  71. Glia. 2005 Oct;52(1):70-7 - PubMed
  72. Nat Rev Neurosci. 2012 Mar 20;13(4):225-39 - PubMed
  73. J Neurochem. 2002 Oct;83(2):463-70 - PubMed
  74. Neuron. 2008 Jun 12;58(5):681-93 - PubMed
  75. Nat Neurosci. 2014 Jan;17(1):131-43 - PubMed
  76. J Clin Invest. 2011 Nov;121(11):4362-71 - PubMed
  77. Neuron. 2013 May 22;78(4):631-43 - PubMed
  78. J Neurosci. 2003 Aug 20;23(20):7504-9 - PubMed
  79. Am J Pathol. 2005 Apr;166(4):1163-72 - PubMed
  80. Alzheimers Dement. 2011 Jul;7(4):402-11 - PubMed
  81. Neuron. 2013 Jan 9;77(1):10-8 - PubMed
  82. N Engl J Med. 2001 Nov 22;345(21):1515-21 - PubMed
  83. J Mol Neurosci. 2005;27(3):303-10 - PubMed
  84. Science. 2003 Dec 5;302(5651):1760-5 - PubMed
  85. Annu Rev Pharmacol Toxicol. 2001;41:661-90 - PubMed
  86. Nat Clin Pract Neurol. 2007 Sep;3(9):496-504 - PubMed
  87. Neurobiol Aging. 2009 May;30(5):759-68 - PubMed
  88. J Neural Transm (Vienna). 2010 Aug;117(8):949-60 - PubMed
  89. Neuroepidemiology. 2004 Jul-Aug;23(4):159-69 - PubMed
  90. Int J Geriatr Psychiatry. 2012 Apr;27(4):364-74 - PubMed
  91. Toxicol Sci. 2006 Jan;89(1):265-70 - PubMed
  92. Alzheimers Dement. 2011 May;7(3):280-92 - PubMed
  93. J Neurosci. 2013 Aug 14;33(33):13320-5 - PubMed
  94. Nature. 1998 Sep 17;395(6699):281-4 - PubMed
  95. N Engl J Med. 2012 Aug 30;367(9):795-804 - PubMed
  96. Int J Dev Neurosci. 2004 Nov;22(7):475-84 - PubMed
  97. J Neurol Neurosurg Psychiatry. 2006 Jan;77(1):85-8 - PubMed
  98. Brain. 2008 Mar;131(Pt 3):651-64 - PubMed
  99. Neurology. 1996 Aug;47(2):425-32 - PubMed

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