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Tremor Other Hyperkinet Mov (N Y). 2017 May 05;7:460. doi: 10.7916/D82Z1BS4. eCollection 2017.

A Case of Myoclonus-Dystonia Responding to Low-frequency Pallidal Stimulation.

Tremor and other hyperkinetic movements (New York, N.Y.)

Harini Sarva, Joan Miravite, Matthew C Swan, Andres Deik, Deborah Raymond, William Lawrence Severt, Brian H Kopell

Affiliations

  1. Parkinson's Disease and Movement Disorders Institute, Department of Neurology, Weill Cornell Medicine, New York, NY, USA.
  2. Department of Neurology, Division of Movement Disorders, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel Medical Center, New York, NY, USA.
  3. Parkinson Disease and Movement Disorders Center, Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
  4. Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Medical Center, New York, NY, USA.

PMID: 28503362 PMCID: PMC5425800 DOI: 10.7916/D82Z1BS4

Abstract

BACKGROUND: High-frequency pallidal stimulation has been shown to improve various types of dystonia, including myoclonus-dystonia.

CASE REPORT: We report a case of epsilon sarcoglycan mutation-negative myoclonus-dystonia with response to low-frequency bilateral pallidal stimulation.

DISCUSSION: Low-frequency pallidal stimulation provides an effective means of treating various dystonias, regardless of genetic status, as in our case, as it provides increased programming options with fewer adverse effects.

Keywords: Myoclonus–dystonia; deep brain stimulation; low-frequency stimulation

Conflict of interest statement

Funding: None. Conflict of Interest: The authors report no conflict of interest. Ethics Statement: This study was reviewed by the authors’ institutional ethics committee and was considered exempted fr

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