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Greenspan KS, Arakelian CR, van Erp TGM. Heritability of Hippocampal Formation Sub-region Volumes. J Neurol Neurosci. 2016;7(6)doi: 10.21767/2171-6625.1000159.
Greenspan, K. S., Arakelian, C. R., & van Erp, T. G. M. (2016). Heritability of Hippocampal Formation Sub-region Volumes. Journal of neurology and neuroscience, 7(6), . https://doi.org/10.21767/2171-6625.1000159
Greenspan, Kiefer S, et al. "Heritability of Hippocampal Formation Sub-region Volumes." Journal of neurology and neuroscience vol. 7,6 (2016). doi: https://doi.org/10.21767/2171-6625.1000159
Greenspan KS, Arakelian CR, van Erp TGM. Heritability of Hippocampal Formation Sub-region Volumes. J Neurol Neurosci. 2016;7(6). doi: 10.21767/2171-6625.1000159. Epub 2016 Nov 14. PMID: 28503392; PMCID: PMC5424602.
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J Neurol Neurosci. 2016;7(6). doi: 10.21767/2171-6625.1000159. Epub 2016 Nov 14.

Heritability of Hippocampal Formation Sub-region Volumes.

Journal of neurology and neuroscience

Kiefer S Greenspan, Claire R Arakelian, Theo G M van Erp

Affiliations

  1. Department of Psychiatry and Human Behavior, University of California, Irvine, SOM.
  2. Department of Psychiatry, University of Pittsburgh, SOM.

PMID: 28503392 PMCID: PMC5424602 DOI: 10.21767/2171-6625.1000159

Abstract

BACKGROUND: Hippocampal formation (HF) volume and episodic memory performance are substantially heritable, but HF subregion heritability estimates and their possible shared genetic variance with episodic memory performance remain to be determined.

METHODS AND FINDINGS: This study provides heritability estimates for hippocampal subregions (e.g, Cornu Amonis, Subiculum, Parasubiculum, Molecular and Granule Cell Layers of the Dentate Gryus) and Total HF volumes obtained using FreeSurfer 6.0. In addition, this study assesses the heritability of object sequence and verbal episodic memory performance, and the amount of shared genetic variance between HF subregions and Total HF volume and episodic memory performance. HF volumes were obtained from high-resolution brain scans from a sample of 499 siblings (mean age±SD=30.0±3.1, 203 men), including 51 monozygotic and 46 dizygotic twin pairs and 305 non-twin siblings, collected by the Human Connectome Project (www.humanconnectome.org). Heritability estimates for HF subregions ranged from 0.42-0.87 and shared genetic variance of HF subregions with hippocampal volume was substantial (mean=0.79, range=0.50-0.98). HF subregion volumes residualized for Total HF and percent HF subregion volumes were also found to be substantially heritable (range=0.04-0.86 and 0.07-0.84, respectively). Verbal (h

CONCLUSIONS: These findings suggest that HF subregion volumes are heritable and can be used as quantitative phenotypes in genetic association studies. The low shared genetic variance between HF subregions and verbal episodic memory suggests that quantitative trait analyses may not benefit from including both HF volume and episodic memory as bivariate traits in healthy individuals. The extent to which HF subregion volumes share genetic variance with neuropsychiatric disorders, and as such add value to our ability to identify genetic risk loci for these disorders, remains to be determined.

Keywords: Human Connectome Project; heritability; hippocampal formation; subfield; subregion; twin

Conflict of interest statement

Conflict of Interest Dr. Van Erp has consulted for Roche Pharmaceuticals and has contract with Otsuka Pharmaceutical Co., Ltd. (OPCJ). The remaining authors declare no potential conflict of interest.

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