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Chen XD, Su MY, Chen TT, et al. Oxidative stress affects retinal pigment epithelial cell survival through epidermal growth factor receptor/AKT signaling pathway. Int J Ophthalmol. 2017;10(4):507-514doi: 10.18240/ijo.2017.04.02.
Chen, X. D., Su, M. Y., Chen, T. T., Hong, H. Y., Han, A. D., & Li, W. S. (2017). Oxidative stress affects retinal pigment epithelial cell survival through epidermal growth factor receptor/AKT signaling pathway. International journal of ophthalmology, 10(4), 507-514. https://doi.org/10.18240/ijo.2017.04.02
Chen, Xiao-Dong, et al. "Oxidative stress affects retinal pigment epithelial cell survival through epidermal growth factor receptor/AKT signaling pathway." International journal of ophthalmology vol. 10,4 (2017): 507-514. doi: https://doi.org/10.18240/ijo.2017.04.02
Chen XD, Su MY, Chen TT, Hong HY, Han AD, Li WS. Oxidative stress affects retinal pigment epithelial cell survival through epidermal growth factor receptor/AKT signaling pathway. Int J Ophthalmol. 2017 Apr 18;10(4):507-514. doi: 10.18240/ijo.2017.04.02. eCollection 2017. PMID: 28503420; PMCID: PMC5406625.
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Int J Ophthalmol. 2017 Apr 18;10(4):507-514. doi: 10.18240/ijo.2017.04.02. eCollection 2017.

Oxidative stress affects retinal pigment epithelial cell survival through epidermal growth factor receptor/AKT signaling pathway.

International journal of ophthalmology

Xiao-Dong Chen, Ming-Yang Su, Tao-Tao Chen, Hai-Yan Hong, Ai-Dong Han, Wen-Sheng Li

Affiliations

  1. Xiamen Eye Center of Xiamen University, Xiamen University, Xiamen 361003, Fujian Province, China.
  2. Department of Ophthalmology, Xi'an No.1 Hospital, Shaanxi Institute of Ophthalmology, Shaanxi Provincial Key Laboratory of Ophthalmology, Xi'an 710002, Shaanxi Province, China.
  3. State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiang'an Campus, Xiamen University, Xiang'an District, Xiamen 361102, Fujian Province, China.

PMID: 28503420 PMCID: PMC5406625 DOI: 10.18240/ijo.2017.04.02

Abstract

AIM: To investigate the cross-talk between oxidative stress and the epidermal growth factor receptor (EGFR)/AKT signaling pathway in retinal pigment epithelial (RPE) cells.

METHODS: Human RPE cell lines (ARPE-19 cell) were treated with different doses of epidermal growth factor (EGF) and hydrogen peroxide (H

RESULTS: EGF treatment increased ARPE-19 cell viability and proliferation through inducing phosphorylation of EGFR and AKT. H

CONCLUSION: Oxidative stress affects RPE cell viability and proliferation through interfering with the EGFR/AKT signaling pathway. The EGFR/AKT signaling pathway may be an important target in oxidative stress-induced RPE cell dysfunction.

Keywords: AKT; epidermal growth factor receptor; oxidative stress; retinal pigment epithelial cell

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