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Shin MS, Kim TW, Lee JM, et al. Treadmill exercise alleviates depressive symptoms in rotenone-induced Parkinson disease rats. J Exerc Rehabil. 2017;13(2):124-129doi: 10.12965/jer.1734966.483.
Shin, M. S., Kim, T. W., Lee, J. M., Sung, Y. H., & Lim, B. V. (2017). Treadmill exercise alleviates depressive symptoms in rotenone-induced Parkinson disease rats. Journal of exercise rehabilitation, 13(2), 124-129. https://doi.org/10.12965/jer.1734966.483
Shin, Mal-Soon, et al. "Treadmill exercise alleviates depressive symptoms in rotenone-induced Parkinson disease rats." Journal of exercise rehabilitation vol. 13,2 (2017): 124-129. doi: https://doi.org/10.12965/jer.1734966.483
Shin MS, Kim TW, Lee JM, Sung YH, Lim BV. Treadmill exercise alleviates depressive symptoms in rotenone-induced Parkinson disease rats. J Exerc Rehabil. 2017 Apr 30;13(2):124-129. doi: 10.12965/jer.1734966.483. eCollection 2017 Apr. PMID: 28503522; PMCID: PMC5412483.
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J Exerc Rehabil. 2017 Apr 30;13(2):124-129. doi: 10.12965/jer.1734966.483. eCollection 2017 Apr.

Treadmill exercise alleviates depressive symptoms in rotenone-induced Parkinson disease rats.

Journal of exercise rehabilitation

Mal-Soon Shin, Tae-Woon Kim, Jae-Min Lee, Yun-Hee Sung, Baek-Vin Lim

Affiliations

  1. School of Global Sport Studies, Korea University, Sejong, Korea.
  2. Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
  3. Department of Physical Therapy, College of Health Sciences, Kyungnam University, Changwon, Korea.
  4. Division of Leisure & Sports Science, Department of Exercise Prescription, Dongseo University, Busan, Korea.

PMID: 28503522 PMCID: PMC5412483 DOI: 10.12965/jer.1734966.483

Abstract

Parkinson disease (PD) is characterized by selective loss of the dopaminergic neurons. The symptoms of depression following PD are closely associated with reduced activity of the serotonergic system in the dorsal raphe. We explored the antidepressive effect of exercise and its possible mechanism using the rotenone-induced PD rats. PD rats were induced by subcutaneously injection with rotenone for 14 days. The rats in the exercise groups were made to run on a treadmill for 30 min once a day during 14 consecutive days. Forced swimming test, immunohistochemistry for serotonin (5-hydroxytryptamine, 5-HT), tryptophan hydroxylase (TPH), and western blot for serotonin 1A (5-HT1A) receptor were conducted. Injection of rotenone induced PD rats. PD rats showed depressive state and treadmill exercise ameliorated this depressive state. 5-HT, TPH, and 5-HT1A receptor expressions in the dorsal raphe were suppressed by rotenone injection and treadmill exercise increased the expressions of 5-HT, TPH, and 5-HT1A receptor in the rotenone-injected rats. The present results show that treadmill exercise ameliorated depressive symptoms in the rotenone-induced PD rats. The antidepressive effect of treadmill exercise might be ascribed to the enhancement of serotonergic function through upregulation of 5-HT1A expression in the dorsal raphe.

Keywords: Parkinson disease; Rotenone; Serotonin; Serotonin 1A receptor; Treadmill exercise

Conflict of interest statement

CONFLICT OF INTEREST No potential conflict of interest relevant to this article was reported.

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