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Guo XF, Hu WP, Lang XZ, et al. Two single nucleotide polymorphisms sites in . J Biol Res (Thessalon). 2017;24:8doi: 10.1186/s40709-017-0065-z.
Guo, X. F., Hu, W. P., Lang, X. Z., Li, Q. L., Wang, X. Y., Di, R., Liu, Q. Y., Liu, X. L., An, Y. F., & Chu, M. X. (2017). Two single nucleotide polymorphisms sites in . Journal of biological research (Thessalonike, Greece), 248. https://doi.org/10.1186/s40709-017-0065-z
Guo, Xiao-Fei, et al. "Two single nucleotide polymorphisms sites in ." Journal of biological research (Thessalonike, Greece) vol. 24 (2017): 8. doi: https://doi.org/10.1186/s40709-017-0065-z
Guo XF, Hu WP, Lang XZ, Li QL, Wang XY, Di R, Liu QY, Liu XL, An YF, Chu MX. Two single nucleotide polymorphisms sites in . J Biol Res (Thessalon). 2017 Apr 13;24:8. doi: 10.1186/s40709-017-0065-z. eCollection 2017 Dec. PMID: 28413783; PMCID: PMC5390408.
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J Biol Res (Thessalon). 2017 Apr 13;24:8. doi: 10.1186/s40709-017-0065-z. eCollection 2017 Dec.

Two single nucleotide polymorphisms sites in .

Journal of biological research (Thessalonike, Greece)

Xiao-Fei Guo, Wen-Ping Hu, Xian-Zheng Lang, Qiu-Ling Li, Xiang-Yu Wang, Ran Di, Qiu-Yue Liu, Xiao-Lin Liu, Yong-Fu An, Ming-Xing Chu

Affiliations

  1. Key Laboratory of Animal Genetics and Breeding and Reproduction of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193 China.
  2. College of Animal Science and Technology, China Agricultural University, Beijing, 100193 China.
  3. College of Animal Science and Technology, Northwest A &F University, Yangling, 712100 China.
  4. Life Sciences College, Langfang Teachers University, Langfang, 065000 China.
  5. Hebei Animal Science and Veterinary Medicine Institute, Baoding, 071000 China.

PMID: 28413783 PMCID: PMC5390408 DOI: 10.1186/s40709-017-0065-z

Abstract

BACKGROUND: Alpha 1-antitrypsin (α1-AT) may affect the susceptibility of mastitis in dairy cattle for its possible role in the protection of lactoferrin from proteolytic degradation in the mammary. Milk somatic cell score (SCS) is a logarithmic transformation of the milk somatic cell count widely used as an index to evaluate mastitis. To study the relationships of

RESULTS: Two polymorphic sites at G5503A and G5746C of

CONCLUSIONS: Statistical analysis indicated that B allele and BBDD genotype combination of α1-AT can improve mastitis resistance in dairy cattle.

Keywords: Chinese Holstein cows; Polymorphism; SNP; Somatic cell score; α1-AT gene

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