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Liang M, Zhang S, Jia J, et al. Synthesis of Spiroketals by Synergistic Gold and Scandium Catalysis. Org Lett. 2017;19(10):2526-2529doi: 10.1021/acs.orglett.7b00804.
Liang, M., Zhang, S., Jia, J., Tung, C. H., Wang, J., & Xu, Z. (2017). Synthesis of Spiroketals by Synergistic Gold and Scandium Catalysis. Organic letters, 19(10), 2526-2529. https://doi.org/10.1021/acs.orglett.7b00804
Liang, Man, et al. "Synthesis of Spiroketals by Synergistic Gold and Scandium Catalysis." Organic letters vol. 19,10 (2017): 2526-2529. doi: https://doi.org/10.1021/acs.orglett.7b00804
Liang M, Zhang S, Jia J, Tung CH, Wang J, Xu Z. Synthesis of Spiroketals by Synergistic Gold and Scandium Catalysis. Org Lett. 2017 May 19;19(10):2526-2529. doi: 10.1021/acs.orglett.7b00804. Epub 2017 May 05. PMID: 28474897.
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Org Lett. 2017 May 19;19(10):2526-2529. doi: 10.1021/acs.orglett.7b00804. Epub 2017 May 05.

Synthesis of Spiroketals by Synergistic Gold and Scandium Catalysis.

Organic letters

Man Liang, Shuai Zhang, Jiong Jia, Chen-Ho Tung, Jianwu Wang, Zhenghu Xu

Affiliations

  1. Key Laboratory for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, China.
  2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , Shanghai 200032, China.

PMID: 28474897 DOI: 10.1021/acs.orglett.7b00804

Abstract

An ultrafast synthesis of spiroketals by synergistic gold(I) and Sc(III) catalysis has been reported. Diverse 5,6-benzannulated spiroketals were rapidly constructed by the diastereoselective [4 + 2] cycloaddition between gold-generated enol ether and Sc(III)-catalyzed o-quinone methide intermediates. Ultrafast reaction rate, ambient reaction temperature, general scope, high yields, excellent diastereoselectivity, and good scalability are attractive features of this method.

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