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Front Chem. 2017 Mar 23;5:13. doi: 10.3389/fchem.2017.00013. eCollection 2017.

Revealing a Novel Otubain-Like Enzyme from .

Frontiers in chemistry

Clênia S Azevedo, Bruna C Guido, Jhonata L Pereira, Diego O Nolasco, Rafael Corrêa, Kelly G Magalhães, Flávia N Motta, Jaime M Santana, Philippe Grellier, Izabela M D Bastos

Affiliations

  1. Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia Brasilia, Brazil.
  2. Laboratory of Electron Microscopy, Department of Cell Biology, University of Brasilia Brasilia, Brazil.
  3. Physics Course, Catholic University of BrasiliaBrasilia, Brazil; Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Catholic University of BrasiliaBrasilia, Brazil.
  4. Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia Brasilia, Brazil.
  5. Pathogen-Host Interface Laboratory, Department of Cell Biology, University of BrasiliaBrasilia, Brazil; Faculty of Ceilandia, University of BrasíliaBrasilia, Brazil.
  6. UMR 7245 Centre Nationnal de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Sorbonne Universités Paris, France.

PMID: 28386537 PMCID: PMC5362604 DOI: 10.3389/fchem.2017.00013

Abstract

Deubiquitinating enzymes (DUBs) play an important role in regulating a variety of eukaryotic processes. In this context, exploring the role of deubiquitination in

Keywords: cysteine protease; deubiquitination; leishmania; molecular dynamic; otubain; site-directed mutagenesis

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