Postepy Dermatol Alergol. 2017 Apr;34(2):131-137. doi: 10.5114/ada.2017.67077. Epub 2017 Apr 13.
Long-term treatment of chronic plaque psoriasis with biological drugs can control platelet activation: targeting the bridge between inflammation and atherothrombosis.
Postepy dermatologii i alergologii
Bartłomiej Kwiek, Joanna Narbutt, Anna Sysa-Jędrzejowska, Andrzej Langner, Aleksandra Lesiak
Affiliations
Affiliations
- Department of Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland.
- Department of Dermatology, Medical University of Lodz, Lodz, Poland.
- Department of Social Sciences, University of Social Sciences, Lodz, Poland.
PMID: 28507492
PMCID: PMC5420605 DOI: 10.5114/ada.2017.67077
Abstract
INTRODUCTION: Platelet activation is elevated in moderate to severe psoriasis, and the reduction in platelet activation during short-term treatment has already been demonstrated. Soluble P-selectin is a well-established marker of platelet activation.
AIM: To show whether the long-term treatment of psoriasis with biological drugs can reduce elevated platelet activation.
MATERIAL AND METHODS: An observational study of 27 patients with chronic plaque psoriasis, treated with infliximab, adalimumab, etanercept, or ustekinumab for up to 12 months was conducted. Psoriasis area and severity index (PASI), serum P-selectin and interleukin (IL)-6 were monitored throughout the treatment.
RESULTS: There was no significant correlation between PASI and platelet activation in our patients. After 3 months of treatment, a significant reduction in PASI and IL-6 was found, while P-selectin was not significantly reduced. When a cohort of patients who had shown elevated P-selectin prior to the treatment was evaluated, a significant reduction in P-selectin was observed in all 8 patients following 3 months; a reduction that was sustained after 6 and 12 months of therapy.
CONCLUSIONS: We conclude that PASI is not a good predictor of platelet activity in patients with PASI near to 10. Biological drugs reduce platelet activation in patients who have increased platelet activation prior to treatment, and this effect is stable during chronic therapy.
Keywords: P-selectin; atherothrombosis; biological; comorbidities; platelets; psoriasis
Conflict of interest statement
The authors declare no conflict of interest.
References
- Am J Med. 2011 Aug;124(8):775.e1-6 - PubMed
- J Intern Med. 2011 Sep;270(3):237-44 - PubMed
- J Rheumatol. 2012 Feb;39(2):334-6 - PubMed
- Acta Derm Venereol. 2008;88(4):337-40 - PubMed
- Br J Dermatol. 2013 Jul;169(1):68-75 - PubMed
- J Am Acad Dermatol. 1995 Jun;32(6):982-6 - PubMed
- J Dermatolog Treat. 2008;19(1):4 - PubMed
- J Invest Dermatol. 2004 Mar;122(3):830-6 - PubMed
- J Am Acad Dermatol. 2014 Jan;70(1):168-77 - PubMed
- J Am Acad Dermatol. 2010 Apr;62(4):621-6 - PubMed
- Br J Dermatol. 2012 Apr;166(4):811-8 - PubMed
- Heart. 2010 Mar;96(6):460-5 - PubMed
- Br J Dermatol. 2012 Dec;167(6):1345-50 - PubMed
- J Am Heart Assoc. 2014 Feb 28;3(1):e000507 - PubMed
- Am J Cardiol. 2009 Feb 2;103(3 Suppl):4A-10A - PubMed
- Clin Rheumatol. 2010 Mar;29(3):325-8 - PubMed
- J Dermatolog Treat. 2008;19(1):5-21 - PubMed
- Exp Dermatol. 2010 Aug;19(8):736-41 - PubMed
- J Rheumatol. 2012 Feb;39(2):210-1 - PubMed
- Postepy Dermatol Alergol. 2016 Aug;33(4):286-9 - PubMed
- J Invest Dermatol. 2011 Jul;131(7):1573-6 - PubMed
- Eur Heart J. 2011 Dec;32(23):2922-32 - PubMed
- N Engl J Med. 2009 Jul 30;361(5):496-509 - PubMed
- Eur J Dermatol. 2014 Jan-Feb;24(1):133-5 - PubMed
Publication Types