Display options
Cite
Fadel F, Bazraa HM, Abdelrahman SM, et al. Visfatin versus Flow-Mediated Dilatation as a Marker of Endothelial Dysfunction in Pediatric Renal Transplant Recipients. Open Access Maced J Med Sci. 2017;5(2):222-227doi: 10.3889/oamjms.2017.032.
Fadel, F., Bazraa, H. M., Abdelrahman, S. M., Shouman, M. G., Sayed, M. K., Salah, D. M., Wahby, A. A., & Elgebaly, H. F. (2017). Visfatin versus Flow-Mediated Dilatation as a Marker of Endothelial Dysfunction in Pediatric Renal Transplant Recipients. Open access Macedonian journal of medical sciences, 5(2), 222-227. https://doi.org/10.3889/oamjms.2017.032
Fadel, Fatina, et al. "Visfatin versus Flow-Mediated Dilatation as a Marker of Endothelial Dysfunction in Pediatric Renal Transplant Recipients." Open access Macedonian journal of medical sciences vol. 5,2 (2017): 222-227. doi: https://doi.org/10.3889/oamjms.2017.032
Fadel F, Bazraa HM, Abdelrahman SM, Shouman MG, Sayed MK, Salah DM, Wahby AA, Elgebaly HF. Visfatin versus Flow-Mediated Dilatation as a Marker of Endothelial Dysfunction in Pediatric Renal Transplant Recipients. Open Access Maced J Med Sci. 2017 Apr 13;5(2):222-227. doi: 10.3889/oamjms.2017.032. eCollection 2017 Apr 15. PMID: 28507632; PMCID: PMC5420778.
Copy Download .nbib Format: NLM
Share it on

Open Access Maced J Med Sci. 2017 Apr 13;5(2):222-227. doi: 10.3889/oamjms.2017.032. eCollection 2017 Apr 15.

Visfatin versus Flow-Mediated Dilatation as a Marker of Endothelial Dysfunction in Pediatric Renal Transplant Recipients.

Open access Macedonian journal of medical sciences

Fatina Fadel, Hafez M Bazraa, Safaa M Abdelrahman, Mohamed Gamal Shouman, Marwa Khaled Sayed, Doaa Mohamed Salah, Aliaa Ahmed Wahby, Heba F Elgebaly

Affiliations

  1. Department of Pediatrics, Center of Pediatric Nephrology and Transplantation (CPNT), Cairo University, Cairo, Egypt.
  2. EGORD, Egyptian Group of Orphan Renal Diseases, Cairo, Egypt.
  3. Department of Pediatrics, National Research Centre, Cairo, Egypt.
  4. Department of Clinical Pathology, National Research Centre, Cairo, Egypt.

PMID: 28507632 PMCID: PMC5420778 DOI: 10.3889/oamjms.2017.032

Abstract

BACKGROUND: Renal transplantation (RTx) is the treatment of choice for paediatric end-stage renal disease (ESRD). A major cause of morbidity and mortality after RTx is cardiovascular disease. Independent predictors of cardiovascular events were shown to constitute an endothelial dysfunction (ED). This study aims to evaluate Visfatin serum level in comparison to brachial artery flow-mediated dilatation (FMD) as a marker of endothelial dysfunction in paediatric RTx recipients.

METHODS: Visfatin serum level has been evaluated in 30 patients on regular hemodialysis (HD), 36 patients post-RTx and 30 controls as a measure for ED, and has been compared to brachial artery FMD.

RESULTS: Visfatin level in transplant recipients was significantly lower than the hemodialysis group as well as FMD was better in transplant recipients. In spite of marked improvement of FMD and marked reduction of visfatin in post-RTx no direct statistical correlation was found between serum Visfatin level and flow-mediated dilatation.

CONCLUSION: Pediatric RTx recipients show lower serum Visfatin level and better FMD than those on regular hemodialysis, reflecting less endothelial dysfunction (ED) and less cardiovascular risk. FMD in kidney transplant recipients tends to be less than normal subjects while visfatin level of the same group is similar to controls. Pediatric RTx appears to have a positive impact on the growth development of children with ESRD.

Keywords: Children; End stage renal disease (ESRD); Endothelial dysfunction (ED); Flow- mediated dilatation (FMD); Renal transplantation (RTx); Visfatin

References

  1. Circulation. 2000 May 23;101(20):2349-54 - PubMed
  2. Circulation. 2002 Feb 5;105(5):546-9 - PubMed
  3. Blood Purif. 2002;20(5):459-61 - PubMed
  4. N Engl J Med. 2002 Dec 19;347(25):2010-9 - PubMed
  5. J Am Soc Nephrol. 2005 Feb;16(2):489-95 - PubMed
  6. Science. 2005 Jan 21;307(5708):426-30 - PubMed
  7. Pol Arch Med Wewn. 2005 Jan;113(1):21-6 - PubMed
  8. Nephrol Dial Transplant. 2006 Jan;21(1):203-7 - PubMed
  9. Am J Nephrol. 2009;29(1):31-5 - PubMed
  10. Clin Transplant. 2009 Mar-Apr;23(2):241-8 - PubMed
  11. J Nephrol. 2011 Mar-Apr;24(2):177-84 - PubMed
  12. Nephrol Dial Transplant. 2012 Aug;27(8):3359-68 - PubMed
  13. EJIFCC. 2009 Apr 20;20(1):73-6 - PubMed
  14. J Pediatr. 1985 Mar;106(3):522-6 - PubMed

Publication Types