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Chem Sci. 2017 Mar 01;8(3):2204-2208. doi: 10.1039/c6sc04218j. Epub 2016 Dec 09.

Psychosine variants as antigens for natural killer T cells.

Chemical science

S Deng, L Kain, C S Pereira, S Mata, M F Macedo, A Bendelac, L Teyton, P B Savage

Affiliations

  1. Department of Chemistry and Biochemistry , Brigham Young University , Provo , UT84602 , USA . Email: [email protected].
  2. Department of Immunology , The Scripps Research Institute , La Jolla , CA 92037 , USA.
  3. Instituto de Investigação e Inovação em Saúde , Universidade do Porto , Portugal.
  4. IBMC - Instituto de Biologia Molecular e Celular , Universidade do Porto , Porto , Portugal.
  5. Department of Medical Sciences , University of Aveiro , Aveiro , Portugal.
  6. Committee on Immunology and Department of Pathology , Howard Hughes Medical Institute , University of Chicago , Chicago , IL 60637 , USA.

PMID: 28507675 PMCID: PMC5408565 DOI: 10.1039/c6sc04218j

Abstract

Natural killer T (NKT) cells play a central role in the interface between innate and adaptive immunity, and alpha-galactosylceramide was recently shown to be an endogenous antigen for these cells. The source of alpha-galactosylceramide has not yet been determined; however,

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