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Org Lett. 2017 May 19;19(10):2494-2497. doi: 10.1021/acs.orglett.7b00715. Epub 2017 Apr 27.

Traceless Directing-Group Strategy in the Ru-Catalyzed, Formal [3 + 3] Annulation of Anilines with Allyl Alcohols: A One-Pot, Domino Approach for the Synthesis of Quinolines.

Organic letters

Gangam Srikanth Kumar, Pravin Kumar, Manmohan Kapur

Affiliations

  1. Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal Bypass Road, Bhauri, Bhopal 462066, MP, India.

PMID: 28448156 DOI: 10.1021/acs.orglett.7b00715

Abstract

A unique, ruthenium-catalyzed, [3 + 3] annulation of anilines with allyl alcohols in the synthesis of substituted quinolines is reported. The method employs a traceless directing group strategy in the proximal C-H bond activation and represents a one-pot Domino synthesis of quinolines from anilines.

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