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Konno G, Someya G, Sekine K, et al. A case of the "cellular variant" of focal segmental glomerulosclerosis with acute renal failure that remitted completely with oral steroid administration. CEN Case Rep. 2012;1(2):77-81doi: 10.1007/s13730-012-0017-2.
Konno, G., Someya, G., Sekine, K., Nishino, T., & Kawamoto, S. (2012). A case of the "cellular variant" of focal segmental glomerulosclerosis with acute renal failure that remitted completely with oral steroid administration. CEN case reports, 1(2), 77-81. https://doi.org/10.1007/s13730-012-0017-2
Konno, Gaku, et al. "A case of the "cellular variant" of focal segmental glomerulosclerosis with acute renal failure that remitted completely with oral steroid administration." CEN case reports vol. 1,2 (2012): 77-81. doi: https://doi.org/10.1007/s13730-012-0017-2
Konno G, Someya G, Sekine K, Nishino T, Kawamoto S. A case of the "cellular variant" of focal segmental glomerulosclerosis with acute renal failure that remitted completely with oral steroid administration. CEN Case Rep. 2012 Nov;1(2):77-81. doi: 10.1007/s13730-012-0017-2. Epub 2012 Jun 19. PMID: 28509069; PMCID: PMC5413643.
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CEN Case Rep. 2012 Nov;1(2):77-81. doi: 10.1007/s13730-012-0017-2. Epub 2012 Jun 19.

A case of the "cellular variant" of focal segmental glomerulosclerosis with acute renal failure that remitted completely with oral steroid administration.

CEN case reports

Gaku Konno, Go Someya, Kazuma Sekine, Takuya Nishino, Shinya Kawamoto

Affiliations

  1. Department of Internal Medicine, Nippon Kokan Hospital, 1-2-1 Kokan-dori, Kawasaki-ku, Kawasaki, Kanagawa, 210-0852, Japan.
  2. Department of Internal Medicine, Nippon Kokan Hospital, 1-2-1 Kokan-dori, Kawasaki-ku, Kawasaki, Kanagawa, 210-0852, Japan. [email protected].
  3. Department of Nephrology, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-koshigaya, Koshigaya, Saitama, 343-8555, Japan. [email protected].

PMID: 28509069 PMCID: PMC5413643 DOI: 10.1007/s13730-012-0017-2

Abstract

A 73-year-old man with systemic edema and oliguria, which appeared within several days, was referred to our hospital. Urinalysis showed massive proteinuria, and the blood examination results indicated nephrotic syndrome. Renal biopsy revealed the existence of focal segmental glomerulosclerosis (FSGS), and further investigation indicated that the microscopic features were consistent with the "cellular variant (CELL)" according to the Columbia Classification. After biopsy, 40 mg per day of oral prednisolone was administered daily. With steroid therapy, the abnormal values of the blood examination and urinalysis gradually reached normal, and complete remission was achieved on day 43 after initiating steroid administration. Microscopic investigation by follow-up renal re-biopsy revealed several sclerosing glomeruli; however, other intact glomeruli had no endothelial proliferation, which is a hallmark of CELL. The patient was discharged after biopsy and observed as an outpatient, with maintenance of clinical remission.

Keywords: Acute renal failure; Cellular variant; Columbia Classification; Focal segmental glomerulosclerosis; Nephrotic syndrome; Oral steroid administration

References

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