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Ryu HS, Kim MS, You S, et al. Comparison of Pallidal and Subthalamic Deep Brain Stimulation in Parkinson's Disease: Therapeutic and Adverse Effects. J Mov Disord. 2017;10(2):80-86doi: 10.14802/jmd.17001.
Ryu, H. S., Kim, M. S., You, S., Kim, M. J., Kim, Y. J., Kim, J., Kim, K., & Chung, S. J. (2017). Comparison of Pallidal and Subthalamic Deep Brain Stimulation in Parkinson's Disease: Therapeutic and Adverse Effects. Journal of movement disorders, 10(2), 80-86. https://doi.org/10.14802/jmd.17001
Ryu, Ho-Sung, et al. "Comparison of Pallidal and Subthalamic Deep Brain Stimulation in Parkinson's Disease: Therapeutic and Adverse Effects." Journal of movement disorders vol. 10,2 (2017): 80-86. doi: https://doi.org/10.14802/jmd.17001
Ryu HS, Kim MS, You S, Kim MJ, Kim YJ, Kim J, Kim K, Chung SJ. Comparison of Pallidal and Subthalamic Deep Brain Stimulation in Parkinson's Disease: Therapeutic and Adverse Effects. J Mov Disord. 2017 May;10(2):80-86. doi: 10.14802/jmd.17001. Epub 2017 May 08. PMID: 28479586; PMCID: PMC5435836.
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J Mov Disord. 2017 May;10(2):80-86. doi: 10.14802/jmd.17001. Epub 2017 May 08.

Comparison of Pallidal and Subthalamic Deep Brain Stimulation in Parkinson's Disease: Therapeutic and Adverse Effects.

Journal of movement disorders

Ho-Sung Ryu, Mi-Sun Kim, Sooyeoun You, Mi-Jung Kim, Young Jin Kim, Juyeon Kim, Kiju Kim, Sun Ju Chung

Affiliations

  1. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  2. Department of Neurology, Dongsan Medical Center, Keimyung University, Daegu, Korea.
  3. Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
  4. Department of Neurology, Best Heals Hospital, Ansan, Korea.
  5. Department of Neurology, Metro Hospital, Anyang, Korea.

PMID: 28479586 PMCID: PMC5435836 DOI: 10.14802/jmd.17001

Abstract

OBJECTIVE: To compare the therapeutic and adverse effects of globus pallidus interna (GPi) and subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of advanced Parkinson's disease (PD).

METHODS: We retrospectively analyzed the clinical data of patients with PD who underwent GPi (n = 14) or STN (n = 28) DBS surgery between April 2002 and May 2014. The subjects were matched for age at surgery and disease duration. The Unified Parkinson's Disease Rating Scale (UPDRS) scores and levodopa equivalent dose (LED) at baseline and 12 months after surgery were used to assess the therapeutic effects of DBS. Adverse effects were also compared between the two groups.

RESULTS: At 12 months, the mean changes in the UPDRS total and part I-IV scores did not differ significantly between the two groups. However, the subscores for gait disturbance/postural instability and dyskinesia were significantly more improved after GPi DBS than those after STN DBS (

CONCLUSION: The patients with PD showed greater improvement in gait disturbance/postural instability and dyskinesia after GPi DBS compared with those after STN DBS, although the patients had a greater reduction in LED after STN DBS. These results may provide useful information for optimal target selection for DBS in PD.

Keywords: Parkinson’s disease; deep brain stimulation; globus pallidus interna; subthalamic nucleus.

References

  1. Mov Disord. 2006 Jun;21 Suppl 14:S290-304 - PubMed
  2. Arch Neurol. 2005 Apr;62(4):554-60 - PubMed
  3. Brain. 2005 Oct;128(Pt 10):2240-9 - PubMed
  4. J Neurophysiol. 2007 Apr;97(4):2627-41 - PubMed
  5. N Engl J Med. 2010 Jun 3;362(22):2077-91 - PubMed
  6. Exp Neurol. 2005 Aug;194(2):523-9 - PubMed
  7. Ann Neurol. 2015 Apr;77(4):710-9 - PubMed
  8. Mov Disord. 2008 Dec 15;23(16):2404-6 - PubMed
  9. J Neurol Neurosurg Psychiatry. 2005 Mar;76(3):426-8 - PubMed
  10. J Neurol. 2012 Jun;259(6):1244-6 - PubMed
  11. N Engl J Med. 1998 Oct 15;339(16):1130-43 - PubMed
  12. Neuroscientist. 2004 Jun;10(3):247-59 - PubMed
  13. J Neurosurg. 2005 Dec;103(6):956-67 - PubMed
  14. Stereotact Funct Neurosurg. 2015 ;93(1):25-9 - PubMed
  15. Gait Posture. 2002 Aug;16(1):1-14 - PubMed
  16. J Neurol Neurosurg Psychiatry. 2001 Apr;70(4):464-70 - PubMed
  17. Lancet Neurol. 2010 Jun;9(6):581-91 - PubMed
  18. Ann Neurol. 2016 Nov;80(5):644-659 - PubMed
  19. J Neurol Neurosurg Psychiatry. 2005 Dec;76(12):1640-4 - PubMed
  20. Neurosci Lett. 1996 Aug 30;215(1):17-20 - PubMed
  21. Lancet Neurol. 2007 Jan;6(1):63-74 - PubMed
  22. Mov Disord. 2016 Sep;31(9):1389-97 - PubMed
  23. N Engl J Med. 2003 Nov 13;349(20):1925-34 - PubMed
  24. Neurology. 2012 Jul 3;79(1):55-65 - PubMed
  25. Lancet. 1995 Jan 14;345(8942):91-5 - PubMed
  26. Mov Disord. 2010 Nov 15;25(15):2649-53 - PubMed
  27. J Neurol Sci. 2016 Oct 15;369:230-5 - PubMed
  28. Lancet Neurol. 2012 Feb;11(2):140-9 - PubMed
  29. Ann Neurol. 2009 May;65(5):586-95 - PubMed
  30. Neurology. 1990 Oct;40(10):1529-34 - PubMed
  31. Brain. 1998 Mar;121 ( Pt 3):451-7 - PubMed
  32. Neurology. 2008 Apr 15;70(16 Pt 2):1403-10 - PubMed
  33. Gait Posture. 2017 Feb;52:205-210 - PubMed
  34. N Engl J Med. 1998 Oct 8;339(15):1044-53 - PubMed
  35. Eur Neurol. 2006;56(2):127-32 - PubMed
  36. J Neuropathol Exp Neurol. 1991 Nov;50(6):743-55 - PubMed
  37. N Engl J Med. 2012 Oct 18;367(16):1529-38 - PubMed
  38. Acta Neurochir (Wien). 2011 Aug;153(8):1573-8 - PubMed

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