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Alvarez AM, Neubeck S, Parra S, et al. Serum Protein Profile in Women With Pregnancy Morbidity Associated With Antiphospholipid Syndrome. J Hum Reprod Sci. 2017;10(1):10-17doi: 10.4103/0974-1208.204018.
Alvarez, A. M., Neubeck, S., Parra, S., Markert, U. R., & Cadavid, A. P. (2017). Serum Protein Profile in Women With Pregnancy Morbidity Associated With Antiphospholipid Syndrome. Journal of human reproductive sciences, 10(1), 10-17. https://doi.org/10.4103/0974-1208.204018
Alvarez, Angela M, et al. "Serum Protein Profile in Women With Pregnancy Morbidity Associated With Antiphospholipid Syndrome." Journal of human reproductive sciences vol. 10,1 (2017): 10-17. doi: https://doi.org/10.4103/0974-1208.204018
Alvarez AM, Neubeck S, Parra S, Markert UR, Cadavid AP. Serum Protein Profile in Women With Pregnancy Morbidity Associated With Antiphospholipid Syndrome. J Hum Reprod Sci. 2017 Jan-Mar;10(1):10-17. doi: 10.4103/0974-1208.204018. PMID: 28479750; PMCID: PMC5405641.
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J Hum Reprod Sci. 2017 Jan-Mar;10(1):10-17. doi: 10.4103/0974-1208.204018.

Serum Protein Profile in Women With Pregnancy Morbidity Associated With Antiphospholipid Syndrome.

Journal of human reproductive sciences

Angela M Alvarez, Stefan Neubeck, Sergio Parra, Udo R Markert, Angela P Cadavid

Affiliations

  1. Reproduction Group, Department of Microbiology and Parasitology, School of Medicine, Universidad de Antioquia, Medellín, Colombia.
  2. Department of Obstetrics, University Hospital Jena, Jena, Germany.
  3. Department of Pharmacology and Toxicology, Universidad de Antioquia, Medellín, Colombia.

PMID: 28479750 PMCID: PMC5405641 DOI: 10.4103/0974-1208.204018

Abstract

CONTEXT: Antiphospholipid antibodies (aPL) are related with a high risk of pregnancy morbidity (PM) and also of vascular thrombosis. On the basis of recent studies, we expect that in women with PM associated with antiphospholipid syndrome (APS), further factors may be deregulated and involved in pathophysiology of the disease. Such factors may have the potential to become novel biomarkers for APS and its stages.

SETTINGS AND DESIGN: Descriptive study from a recurrent pregnancy loss program.

AIMS: To study the protein expression in sera from women with PM with or without aPL.

MATERIALS AND METHODS: Protein profiles were determined by surface enhanced laser desorption and ionization - time of flight mass spectrometry (SELDI-TOF MS) in the serum samples from women with PM, 10 of them with aPL and 12 without aPL. On the basis of the mass-to-charge ratio (

STATISTICAL ANALYSIS USED: To determine the differential expression of each protein, a no paired

RESULTS: SELDI-TOF analysis makes it possible to discriminate between several proteins in women with PM with and without aPL, although it does not allow protein identification. Nine proteins were found in significantly higher levels in aPL-positive women.

CONCLUSION: The results underline that further factors beyond autoantibodies are involved in PM associated with APS and might lead to the development of new biomarkers.

Keywords: Antiphospholipid antibodies; SELDI-TOF MS; pregnancy loss; proteomics

Conflict of interest statement

There are no conflicts of interest.

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