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Open Forum Infect Dis. 2017 Jan 13;4(1):ofw268. doi: 10.1093/ofid/ofw268. eCollection 2017.

Trends in Hospitalizations Related to Invasive Aspergillosis and Mucormycosis in the United States, 2000-2013.

Open forum infectious diseases

Snigdha Vallabhaneni, Kaitlin Benedict, Gordana Derado, Rajal K Mody

Affiliations

  1. Mycotic Diseases Branch, Division for Food, Water, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  2. Biostatistics and Information Management Office, Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

PMID: 28480260 PMCID: PMC5413990 DOI: 10.1093/ofid/ofw268

Abstract

BACKGROUND: Invasive aspergillosis (IA) and mucormycosis contribute to substantial mortality, especially among immunocompromised persons, including those with hematopoietic stem cell transplant (HSCT), hematologic malignancy (HM), and solid organ transplant (SOT).

METHODS: Using

RESULTS: There were an estimated 169 110 IA-RH and 9966 M-RH during 2000-2013. Overall, IA-RH and M-RH rates per million persons rose from 32.8 to 46.0 (APC = +2.9;

CONCLUSIONS: Overall IA-RH and M-RH rates increased during 2000-2013, with a doubling of M-RH. Mucormycosis-related hospitalization occurring in conjunction with certain comorbidities increased, whereas IA-RH rates among patients with the comorbidities, decreased, remained stable, or increased to a lesser extent than M-RH.

Published by Oxford University Press on behalf of Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Keywords: burden; immunocompromised population; invasive aspergillosis; mucormycosis; trends

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